Corica Ferdinando, De Feo Maria Silvia, Gorica Joana, Sidrak Marko Magdi Abdou, Conte Miriam, Filippi Luca, Schillaci Orazio, De Vincentis Giuseppe, Frantellizzi Viviana
Department of Radiological Sciences, Oncology and Anatomo-Pathology, Sapienza University of Rome, 00185 Rome, Italy.
Department of Nuclear Medicine, Santa Maria Goretti Hospital, 04100 Latina, Italy.
Diagnostics (Basel). 2023 Mar 8;13(6):1029. doi: 10.3390/diagnostics13061029.
Parkinson's disease is the second most common neurodegenerative disorder, affecting 2-3% of the population of patients >65 years. Although the standard diagnosis of PD is clinical, neuroimaging plays a key role in the evaluation of patients who present symptoms related to neurodegenerative disorders. MRI, DAT-SPECT, and PET with [F]-FDG are routinely used in the diagnosis and focus on the investigation of morphological changes, nigrostriatal degeneration or shifts in glucose metabolism in patients with parkinsonian syndromes. The aim of this study is to review the current PET radiotracers targeting TSPO, a transmembrane protein that is overexpressed by microglia in another pathophysiological process associated with neurodegenerative disorders known as neuroinflammation. To the best of our knowledge, neuroinflammation is present not only in PD but in many other neurodegenerative disorders, including AD, DLB, and MSA, as well as atypical parkinsonian syndromes. Therefore, in this study, specific patterns of microglial activation in PD and the differences in distribution volumes of these radiotracers in patients with PD as compared to other neurodegenerative disorders are reviewed.
帕金森病是第二常见的神经退行性疾病，影响着2%至3%的65岁以上人群。尽管帕金森病的标准诊断是临床诊断，但神经影像学在评估出现与神经退行性疾病相关症状的患者中起着关键作用。MRI、DAT-SPECT和[F]-FDG PET通常用于诊断，重点是研究帕金森综合征患者的形态学变化、黑质纹状体变性或葡萄糖代谢变化。本研究的目的是综述目前针对TSPO的PET放射性示踪剂，TSPO是一种跨膜蛋白，在与神经退行性疾病相关的另一种病理生理过程即神经炎症中，被小胶质细胞过度表达。据我们所知，神经炎症不仅存在于帕金森病中，还存在于许多其他神经退行性疾病中，包括阿尔茨海默病、路易体痴呆和多系统萎缩，以及非典型帕金森综合征。因此，在本研究中，我们综述了帕金森病中小胶质细胞激活的特定模式，以及与其他神经退行性疾病相比，这些放射性示踪剂在帕金森病患者中的分布体积差异。
