Gerhard Alexander
Wolfson Molecular Imaging Centre, Institute of Brain, Behaviour and Mental Health, The University of Manchester, 27 Palatine Road, Withington, Manchester, M20 3LJ UK.
Clin Transl Imaging. 2016;4:183-190. doi: 10.1007/s40336-016-0171-1. Epub 2016 Apr 11.
Microglial activation is a key aspect of the neuroinflammatory process in neurodegenerative disorders including idiopathic and atypical parkinsonian disorders. With positron emission tomography (PET) it has become possible to image this phenomenon in vivo and over the last years patterns of microglia activation corresponding with the known distribution of neuropathological changes in these disorders have been demonstrated using this technique. In addition the effects of interventions aimed at suppressing microglia activation as part of interventional trials have successfully been demonstrated. Current research aims at evaluating PET tracers for microglial activation with more favorable properties than the prototypical [C]-()-PK11195, as well as developing tracers targeting additional parameters of the neuroinflammatory process like astroglial function.
小胶质细胞激活是神经退行性疾病（包括特发性和非典型帕金森氏症）神经炎症过程的一个关键方面。借助正电子发射断层扫描（PET）技术，已能够在体内对这一现象进行成像，并且在过去几年中，利用该技术已证实了与这些疾病中已知神经病理变化分布相对应的小胶质细胞激活模式。此外，作为干预试验的一部分，旨在抑制小胶质细胞激活的干预措施的效果也已得到成功证实。当前的研究旨在评估具有比典型的[C]-()-PK11195更优良特性的用于小胶质细胞激活的PET示踪剂，以及开发针对神经炎症过程其他参数（如星形胶质细胞功能）的示踪剂。
