Seifen Christopher, Pordzik Johannes, Huppertz Tilman, Hackenberg Berit, Schupp Cornelia, Matthias Christoph, Simon Perikles, Gouveris Haralampos
Sleep Medicine Center, Department of Otolaryngology, Head and Neck Surgery, University Medical Center Mainz, 55131 Mainz, Germany.
Department of Sports Medicine, Disease Prevention and Rehabilitation, Johannes Gutenberg University, 55099 Mainz, Germany.
Diagnostics (Basel). 2023 Mar 17;13(6):1154. doi: 10.3390/diagnostics13061154.
Obstructive sleep apnea (OSA) has been associated with various acute and chronic inflammatory diseases, as has serum ferritin, an intracellular iron storage protein. Little is known about the relationship between severity of OSA and serum ferritin levels in otherwise healthy subjects. In this study, all polysomnographic recordings, serum levels of ferritin, C-reactive protein (CRP), and hemoglobin, as well as patient files from 90 consecutive, otherwise healthy individuals with suspected OSA who presented to a tertiary sleep medical center were retrospectively analyzed. For comparison, three groups were formed based on apnea-hypopnea index (AHI; none or mild OSA: <15/h vs. moderate OSA: 15-30/h vs. severe OSA: >30/h). Serum ferritin levels were significantly positively correlated with AHI (r = 0.3240, = 0.0020). A clear trend of higher serum ferritin levels was found when patients with severe OSA were compared to those without or with mild OSA. Serum CRP and serum hemoglobin levels did not differ significantly among OSA severity groups. Age and body-mass index (BMI) tended to be higher with increasing OSA severity. The BMI was significant higher in patients with severe OSA compared to those without or with mild ( < 0.001). Therefore, serum ferritin levels may provide a biochemical surrogate marker for OSA severity.
阻塞性睡眠呼吸暂停（OSA）与多种急慢性炎症性疾病相关，细胞内铁储存蛋白血清铁蛋白也是如此。对于健康人群中OSA严重程度与血清铁蛋白水平之间的关系，人们知之甚少。在本研究中，我们对一家三级睡眠医学中心连续收治的90例疑似OSA的健康个体的所有多导睡眠图记录、血清铁蛋白、C反应蛋白（CRP）和血红蛋白水平，以及患者档案进行了回顾性分析。为作比较，根据呼吸暂停低通气指数（AHI）将研究对象分为三组（无或轻度OSA：<15次/小时；中度OSA：15 - 30次/小时；重度OSA：>30次/小时）。血清铁蛋白水平与AHI显著正相关（r = 0.3240，P = 0.0020）。与无OSA或轻度OSA患者相比，重度OSA患者血清铁蛋白水平呈明显升高趋势。OSA严重程度不同的组间血清CRP和血清血红蛋白水平无显著差异。随着OSA严重程度增加，年龄和体重指数（BMI）有升高趋势。重度OSA患者的BMI显著高于无OSA或轻度OSA患者（P < 0.001）。因此，血清铁蛋白水平可能为OSA严重程度提供一种生化替代标志物。
