Cheng Esther T W, Au Chun T, Chan Raymond N C, Chan Joey W Y, Chan Ngan Y, Wing Yun K, Li Albert M, Lam Ethan, Chan Kate C
Department of Paediatrics, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong SAR, China.
Translational Medicine, Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada.
Sleep Adv. 2024 Jul 18;5(1):zpae048. doi: 10.1093/sleepadvances/zpae048. eCollection 2024.
To explore markers that reflect sleep-disordered breathing (SDB) severity and investigate their associations with cardiometabolic risk factors in adolescents and young adults.
Participants were recruited from our SDB epidemiological cohort. They underwent overnight polysomnography and ambulatory blood pressure (BP) monitoring. Complete blood count, ferritin, high-sensitivity C-reactive protein (hs-CRP), fasting blood glucose, and lipid profile were measured. Multiple linear regression was used to examine the association between red cell indices (RCIs), ferritin, and obstructive apnea-hypopnea index (OAHI). Subgroup analyses on participants with SDB were performed for the association of RCIs and ferritin with lipid profile, hs-CRP, and BP.
There were 88 participants with SDB and 155 healthy controls aged 16-25 years. Hemoglobin (Hb; < .001), hematocrit (HCT; < .001), and ferritin ( < .001) were elevated with increasing SDB severity and were independently associated with OAHI (β=1.06, < .001; =40.2, < .001; =4.89 × 10, = .024, respectively). In participants with SDB, after adjusting for age, sex, and BMI, significant associations were found between ferritin with low-density lipoprotein (LDL; =0.936 × 10, = .008) and triglyceride (TG; =1.08 × 10, < .001), as well as between Hb (=1.40, = .007), HCT (=51.5, = .010) and mean arterial pressure (MAP). Ferritin (=0.091, = .002), Hb (=0.975, = .005), and HCT (=38.8, = .004) were associated with hs-CRP independent of age, sex, BMI, plasma LDL, and MAP. OAHI was not associated with LDL and TG in the multivariable models.
Serum ferritin, but not OAHI, was associated with LDL and TG in participants with SDB, suggesting it is a potential marker of cardiometabolic risk in patients with SDB.
探索反映睡眠呼吸障碍（SDB）严重程度的标志物，并研究其与青少年和青年人心血管代谢危险因素的关联。
参与者来自我们的SDB流行病学队列。他们接受了夜间多导睡眠图和动态血压（BP）监测。测量了全血细胞计数、铁蛋白、高敏C反应蛋白（hs-CRP）、空腹血糖和血脂谱。采用多元线性回归分析红细胞指数（RCIs）、铁蛋白与阻塞性呼吸暂停低通气指数（OAHI）之间的关联。对患有SDB的参与者进行亚组分析，以研究RCIs和铁蛋白与血脂谱、hs-CRP和BP之间的关联。
共有88名患有SDB的参与者和155名年龄在16至25岁之间的健康对照者。随着SDB严重程度的增加，血红蛋白（Hb；<0.001）、血细胞比容（HCT；<0.001）和铁蛋白（<0.001）升高，且与OAHI独立相关（β=1.06，<0.001；=40.2，<0.001；=4.89×10，=0.024）。在患有SDB的参与者中，在调整年龄、性别和BMI后，发现铁蛋白与低密度脂蛋白（LDL；=0.936×10，=0.008）和甘油三酯（TG；=1.08×10，<0.001）之间存在显著关联，以及Hb（=1.40，=0.007）、HCT（=51.5，=0.010）与平均动脉压（MAP）之间存在显著关联。铁蛋白（=0.091，=0.002）、Hb（=0.975，=0.005）和HCT（=38.8，=0.004）与hs-CRP的关联独立于年龄、性别、BMI、血浆LDL和MAP。在多变量模型中，OAHI与LDL和TG无关。
在患有SDB的参与者中，血清铁蛋白而非OAHI与LDL和TG相关，这表明它是SDB患者心血管代谢风险的潜在标志物。
