抗人绒毛膜促性腺激素抗体的完整片段和Fab2(1)片段在携带人绒毛膜癌异种移植瘤的裸鼠体内的分布。
Distribution of intact and Fab2(1) fragments of anti-human chorionic gonadotrophin antibodies in nude mice bearing human choriocarcinoma xenografts.
作者信息
Searle F, Adam T, Boden J A
出版信息
Cancer Immunol Immunother. 1986;21(3):205-8. doi: 10.1007/BF00199363.
Abstract
A direct comparative study of the distribution of intact and Fab2(1) fragments of mouse monoclonal anti-human chorionic gonadotrophin antibody, W14A, in nude mice bearing a human choriocarcinoma xenograft, indicates that the tumour:blood ratio is generally improved with fragments. Some parameters which may determine the distribution are outlined.
摘要
一项对小鼠单克隆抗人绒毛膜促性腺激素抗体W14A的完整抗体和Fab2(1)片段在携带人绒毛膜癌异种移植瘤的裸鼠体内分布的直接对比研究表明，片段的肿瘤与血液比值总体上有所改善。文中概述了一些可能决定分布的参数。
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