人乳头瘤病毒（HPV）诱导的皮肤肿瘤的预防与治疗
Prevention and Treatment of HPV-Induced Skin Tumors.
作者信息
Hasche Daniel, Akgül Baki
机构信息
Division of Viral Transformation Mechanisms, Research Program "Infection, Inflammation and Cancer", German Cancer Research Center (DKFZ), Im Neuenheimer Feld 242, 69120 Heidelberg, Germany.
Institute of Virology, Medical Faculty and University Hospital Cologne, University of Cologne, Fürst-Pückler-Str. 56, 50935 Cologne, Germany.
出版信息
Cancers (Basel). 2023 Mar 10;15(6):1709. doi: 10.3390/cancers15061709.
Non-melanoma skin cancer (NMSC) is the most common cancer in humans with increasing incidence. Meanwhile, a growing body of evidence has provided a link between skin infections with HPV of the genus beta (betaHPV) and the development of cutaneous squamous cell carcinomas (cSCCs). Based on this association, the development of vaccines against betaHPV has become an important research topic. This review summarizes the current advances in prophylactic and therapeutic betaHPV vaccines, including progresses made in preclinical testing and clinical trials.
非黑色素瘤皮肤癌（NMSC）是人类中最常见的癌症，其发病率呈上升趋势。与此同时，越来越多的证据表明，皮肤感染β属人乳头瘤病毒（βHPV）与皮肤鳞状细胞癌（cSCC）的发生之间存在联系。基于这种关联，针对βHPV的疫苗研发已成为一个重要的研究课题。本综述总结了预防性和治疗性βHPV疫苗的当前进展，包括临床前测试和临床试验中取得的进展。
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