Duong Huong, Walker Meegan, Maugham-Macan Michelle
School of Health and Behavioural Sciences, University of the Sunshine Coast, Sippy Downs, QLD 4556, Australia.
Cancers (Basel). 2023 Mar 15;15(6):1786. doi: 10.3390/cancers15061786.
The benefits of exercise for patients with cancer are well-established, however, for patients with bone metastases, exercise as adjuvant therapy is underutilised due to concerns for safety, efficacy and other barriers such as the method of delivery. This scoping review explores these barriers by reviewing the results of clinical trials conducted on participants with bone metastases.
A thorough literature search was undertaken using PubMed, Scopus, NIH Clinical Trials and Google Scholar databases. Articles that involved an exercise intervention and patients with bone metastases were included. Data were pooled, charted, analysed and reported according to PRISMA-ScR standards.
A total of 26 trials were reviewed with interventions that included aerobic and resistance training. Only three serious adverse events occurred, not likely related to bone metastases. Nine trials (34.6%) involved unsupervised exercise sessions. Remote exercise delivery had an average of 80.3% compliance, rivalling in-person and mixed supervision. The results of this review reaffirm that exercise helps improve functional capacity, muscle strength, lean mass and cardiovascular function, and is safe in patients with bone metastases irrespective of in-person or remote delivery.
Exercise therapy, whether delivered in person or remotely, is safe and efficacious for patients with bone metastases.
运动对癌症患者的益处已得到充分证实，然而，对于骨转移患者，由于对安全性、疗效以及其他障碍（如实施方式）的担忧，运动作为辅助治疗的应用未得到充分利用。本范围综述通过回顾对骨转移参与者进行的临床试验结果来探讨这些障碍。
使用PubMed、Scopus、美国国立卫生研究院临床试验数据库和谷歌学术数据库进行了全面的文献检索。纳入了涉及运动干预和骨转移患者的文章。根据PRISMA-ScR标准对数据进行汇总、制表、分析和报告。
共审查了26项试验，其干预措施包括有氧运动和抗阻训练。仅发生了3起严重不良事件，不太可能与骨转移有关。9项试验（34.6%）涉及无监督的运动课程。远程运动实施的平均依从率为80.3%，与面对面和混合监督相当。本综述结果再次证实，运动有助于改善功能能力、肌肉力量、瘦体重和心血管功能，并且对于骨转移患者而言，无论采用面对面还是远程实施方式都是安全的。
运动疗法，无论是面对面实施还是远程实施，对骨转移患者都是安全有效的。
