College of Life Science, Yangtze University, Jingzhou 434025, China.
Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
Genes (Basel). 2023 Mar 16;14(3):734. doi: 10.3390/genes14030734.
As an important member of the kindlin family, fermitin family member 1 (FERMT1) can interact with integrin and its aberrant expression involves multiple tumors. However, there are few systematic studies on in pancreatic carcinoma (PAAD). We used several public databases to analyze the expression level and clinicopathological characteristics of in PAAD. Meanwhile, the correlation between expression and diagnostic and prognostic value, methylation, potential biological function, immune infiltration, and sensitivity to chemotherapy drugs in PAAD patients were investigated. was significantly up-regulated in PAAD and correlated with T stage, and histologic grade. High expression was closely connected with poor prognosis and can be used to diagnose PAAD. Moreover, the methylation of six CpG sites of was linked to prognosis, and expression was significantly related to N6-methyladenosine (mA) modification. Functional enrichment analysis revealed that co-expression genes participated in diverse biological functions including necroptosis. In addition, the expression of was associated with immune cell infiltration and the expression of immune checkpoint molecules. Finally, overexpression may be sensitive to chemotherapy drugs such as Palbociclib, AM-5992 and TAE-226. can serve as a diagnostic and prognostic marker of PAAD, which is connected with immune cell infiltration and the modulation of mA and necroptosis.
作为黏着斑激酶家族的重要成员，FERMT1 可以与整合素相互作用，其异常表达涉及多种肿瘤。然而，关于 FERMT1 在胰腺导管腺癌（PAAD）中的研究较少。我们使用了几个公共数据库来分析 FERMT1 在 PAAD 中的表达水平和临床病理特征。同时，研究了 FERMT1 表达与诊断和预后价值、甲基化、潜在生物学功能、免疫浸润以及 PAAD 患者对化疗药物敏感性的相关性。结果表明，FERMT1 在 PAAD 中显著上调，并与 T 分期和组织学分级相关。高表达与预后不良密切相关，可用于诊断 PAAD。此外，FERMT1 的六个 CpG 位点的甲基化与预后相关，并且 FERMT1 表达与 N6-甲基腺苷（mA）修饰显著相关。功能富集分析表明，FERMT1 共表达基因参与了多种生物学功能，包括坏死性凋亡。此外，FERMT1 的表达与免疫细胞浸润和免疫检查点分子的表达相关。最后，过表达 FERMT1 可能对化疗药物如 Palbociclib、AM-5992 和 TAE-226 敏感。FERMT1 可以作为 PAAD 的诊断和预后标志物，与免疫细胞浸润以及 mA 和坏死性凋亡的调节有关。
