Phubbing is defined as the use of one's phone while in a conversation, leading to a disconnection from interpersonal communications. This topic has become more interesting lately due to the increased use of smartphones worldwide and in Lebanon, where 86% of the population owns a smartphone. This study aims to assess the association between phubbing and personality traits with the moderating effects of loneliness and boredom proneness. This cross-sectional study was conducted between August-September 2020. 461 participants (18-29 years) filled out the survey. Higher open-mindedness was associated with less phubbing. Being married compared to single and higher open-mindedness were significantly associated with less phubbing. More boredom was significantly associated with more phubbing. The interaction extraversion by boredom was significantly associated with phubbing; this was significant at low levels of loneliness and boredom where extraversion was significantly associated with more phubbing. At moderate loneliness and high boredom and at high loneliness and boredom, extraversion was significantly associated with less phubbing. The interactions between boredom and loneliness and the other four personality traits did not show any significant association with phubbing. The current study highlights the importance of personality traits in influencing phubbing and might contribute to the preliminary assessment of phubbing. Healthcare professionals might be able to use the data of this study to implement appropriate smartphone use habits, as this would help patients improve their social relationships.