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一种用于测定阿霉素、柔红霉素及其13-羟基代谢物阿霉素醇和柔红霉素醇的快速色谱方法。

A rapid chromatographic procedure for the determination of adriamycin, daunomycin and their 13-OH metabolites adriamycinol and daunomycinol.

作者信息

Erb N, Erttmann R, Landbeck G

出版信息

Cancer Chemother Pharmacol. 1986;17(1):53-5. doi: 10.1007/BF00299866.

DOI:10.1007/BF00299866
PMID:3698178
Abstract

A rapid chromatographic procedure for the quantitative determination of the anthracycline antibiotics adriamycin and daunorubicin and their chief metabolites adriamycinol and daunorubicinol in plasma and urine is described. The extraction is performed using SEP-PAK silica cartridges. After filtration the eluate is chromatographed on a reversed-phase column.

摘要

本文描述了一种快速色谱法，用于定量测定血浆和尿液中的蒽环类抗生素阿霉素和柔红霉素及其主要代谢产物阿霉素醇和柔红霉素醇。使用SEP-PAK硅胶柱进行萃取。过滤后，将洗脱液在反相柱上进行色谱分析。

相似文献

1
A rapid chromatographic procedure for the determination of adriamycin, daunomycin and their 13-OH metabolites adriamycinol and daunomycinol.一种用于测定阿霉素、柔红霉素及其13-羟基代谢物阿霉素醇和柔红霉素醇的快速色谱方法。
Cancer Chemother Pharmacol. 1986;17(1):53-5. doi: 10.1007/BF00299866.
2
Reversed-phase liquid chromatography of adriamycin and daunorubicin and their hydroxyl metabolites adriamycinol and daunorubicinol.阿霉素和柔红霉素及其羟基代谢产物阿霉素醇和柔红霉素醇的反相液相色谱分析
J Chromatogr. 1978 Feb 11;149:225-32. doi: 10.1016/s0021-9673(00)80988-7.
3
Determination of rubidazone and its metabolites in human plasma and urine by reversed-phase ion-pair high-performance liquid chromatography.反相离子对高效液相色谱法测定人血浆和尿液中的鲁比达唑及其代谢物
J Chromatogr. 1986 Aug 2;380(2):455-61. doi: 10.1016/s0378-4347(00)83679-8.
4
Quantitative determination of low levels of daunomycin and daunomycinol in plasma by high-performance liquid chromatography.采用高效液相色谱法定量测定血浆中低水平的柔红霉素和柔红霉素醇。
J Chromatogr. 1976 Sep 29;125(1):369-74. doi: 10.1016/s0021-9673(00)93832-9.
5
Radioimmunoassays for adriamycin and daunomycin.阿霉素和柔红霉素的放射免疫测定法。
Cancer Res. 1974 Oct;34(10):2546-52.
6
Facile and definitive determination of human adriamycin and daunoribicin metabolites by high-pressure liquid chromatography.通过高压液相色谱法简便、准确地测定人阿霉素和柔红霉素代谢物
Drug Metab Dispos. 1980 May-Jun;8(3):152-6.
7
Determination of adriamycin, adriamycinol and their 7-deoxyaglycones in human serum by high-performance liquid chromatography.高效液相色谱法测定人血清中的阿霉素、阿霉素醇及其7-脱氧糖苷配基
J Chromatogr. 1984 Nov 9;311(1):125-33. doi: 10.1016/s0378-4347(00)84698-8.
8
Polarographic determination of doxorubicin and daunorubicin in pharmaceutical preparations and biological media.极谱法测定药物制剂和生物介质中的阿霉素和柔红霉素。
J Pharm Biomed Anal. 1992 Oct-Dec;10(10-12):1053-7. doi: 10.1016/0731-7085(91)80118-s.
9
Reversed-phase liquid chromatographic determination of plasma levels of adriamycin and adriamycinol.反相液相色谱法测定血浆中阿霉素和阿霉素醇的含量。
J Chromatogr. 1979 Dec 1;164(4):479-86. doi: 10.1016/s0378-4347(00)81550-9.
10
Determination of daunorubicin, doxorubicin and their fluorescent metabolites by high-pressure liquid chromatography: plasma levels in DBA2 mice.通过高压液相色谱法测定柔红霉素、阿霉素及其荧光代谢产物：DBA2小鼠的血浆水平
Cancer Chemother Pharmacol. 1979;2(1):11-4. doi: 10.1007/BF00253098.

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1
Rapid determination of PEGylated liposomal doxorubicin and its major metabolite in human plasma by ultraviolet-visible high-performance liquid chromatography.紫外可见高效液相色谱法快速测定人血浆中聚乙二醇化脂质体阿霉素及其主要代谢物
J Chromatogr B Analyt Technol Biomed Life Sci. 2002 Nov 5;779(2):259-69. doi: 10.1016/s1570-0232(02)00395-1.
2
Pharmacokinetics of doxorubicin in man: dose and schedule dependence.阿霉素在人体中的药代动力学：剂量与给药方案依赖性。
J Cancer Res Clin Oncol. 1988;114(5):509-13. doi: 10.1007/BF00391502.
3
Use of plasma cytotoxic activity to model cytotoxic pharmacodynamics of anticancer drugs.

本文引用的文献

1
Adriamycin-a review.阿霉素综述
J Natl Cancer Inst. 1975 Dec;55(6):1265-74. doi: 10.1093/jnci/55.6.1265.
2
Quantitative determination of low levels of daunomycin and daunomycinol in plasma by high-performance liquid chromatography.采用高效液相色谱法定量测定血浆中低水平的柔红霉素和柔红霉素醇。
J Chromatogr. 1976 Sep 29;125(1):369-74. doi: 10.1016/s0021-9673(00)93832-9.
3
Liquid chromatographic determination of daunorubicin and daunorubicinol in plasma from leukemic patients.白血病患者血浆中柔红霉素和柔红霉醇的液相色谱测定法
Cancer Chemother Pharmacol. 1991;29(2):133-40. doi: 10.1007/BF00687323.
J Chromatogr. 1978 Jun 1;153(1):211-8. doi: 10.1016/s0021-9673(00)89874-x.
4
Measurement of adriamycin (doxorubicin) and its metabolites in human plasma using reversed-phase high-performance liquid chromatography and fluorescence detection.
J Chromatogr. 1979 Dec 1;164(4):471-8. doi: 10.1016/s0378-4347(00)81549-2.
5
Daunorubicin and adriamycin in cancer treatment: an analysis of their roles and limitations.
Cancer Treat Rep. 1979 May;63(5):809-15.