一种用于测定阿霉素、柔红霉素及其13-羟基代谢物阿霉素醇和柔红霉素醇的快速色谱方法。
A rapid chromatographic procedure for the determination of adriamycin, daunomycin and their 13-OH metabolites adriamycinol and daunomycinol.
作者信息
Erb N, Erttmann R, Landbeck G
出版信息
Cancer Chemother Pharmacol. 1986;17(1):53-5. doi: 10.1007/BF00299866.
PMID:3698178
Abstract
A rapid chromatographic procedure for the quantitative determination of the anthracycline antibiotics adriamycin and daunorubicin and their chief metabolites adriamycinol and daunorubicinol in plasma and urine is described. The extraction is performed using SEP-PAK silica cartridges. After filtration the eluate is chromatographed on a reversed-phase column.
摘要
本文描述了一种快速色谱法，用于定量测定血浆和尿液中的蒽环类抗生素阿霉素和柔红霉素及其主要代谢产物阿霉素醇和柔红霉素醇。使用SEP-PAK硅胶柱进行萃取。过滤后，将洗脱液在反相柱上进行色谱分析。
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本文引用的文献
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Adriamycin-a review.阿霉素综述
J Natl Cancer Inst. 1975 Dec;55(6):1265-74. doi: 10.1093/jnci/55.6.1265.
2
Quantitative determination of low levels of daunomycin and daunomycinol in plasma by high-performance liquid chromatography.采用高效液相色谱法定量测定血浆中低水平的柔红霉素和柔红霉素醇。
J Chromatogr. 1976 Sep 29;125(1):369-74. doi: 10.1016/s0021-9673(00)93832-9.
3
Liquid chromatographic determination of daunorubicin and daunorubicinol in plasma from leukemic patients.白血病患者血浆中柔红霉素和柔红霉醇的液相色谱测定法
J Chromatogr. 1978 Jun 1;153(1):211-8. doi: 10.1016/s0021-9673(00)89874-x.
4
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Daunorubicin and adriamycin in cancer treatment: an analysis of their roles and limitations.
Cancer Treat Rep. 1979 May;63(5):809-15.
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