Institut de Recherche Biomédicale des Armées (IRBA), 91223 Brétigny sur Orge, France.
URP 7330 VIFASOM, Université Paris Cité, Hôtel-Dieu, 75004 Paris, France.
Int J Environ Res Public Health. 2023 Mar 11;20(6):4971. doi: 10.3390/ijerph20064971.
(1) Background: Caffeine is a psychostimulant that is well known to mitigate the deleterious effects of sleep debt. Our aim was to assess the effects of acute caffeine intake on cognitive vulnerability and brain activity during total sleep deprivation (TSD), taking into account habitual caffeine consumption. (2) Methods: Thirty-seven subjects were evaluated in a double-blind, crossover, total sleep deprivation protocol with caffeine or placebo treatment. Vigilant attention was evaluated every six hours during TSD using the psychomotor vigilance test (PVT) with EEG recordings. The influence of habitual caffeine consumption was analyzed by categorizing subjects into low, moderate, and high consumers. (3) Results: The PVT reaction time (RT) increased during TSD and was lower in the caffeine condition vs. the placebo condition. The RT was shorter in the low-caffeine consumers compared to moderate and high consumers, regardless of conditions and treatments. The TSD-related increase in EEG power was attenuated by acute caffeine intake independently of habitual caffeine consumption, and the individual alpha frequency (IAF) was lower in the high-consumption group. The IAF was negatively correlated with daytime sleepiness. Moreover, a correlation analysis showed that the higher the daily caffeine consumption, the higher the RT and the lower the IAF. (4) Conclusions: A high level of habitual caffeine consumption decreases attentional performance and alpha frequencies, decreasing tolerance to sleep deprivation.
(1) 背景：咖啡因是一种众所周知的精神兴奋剂，可减轻睡眠债务的有害影响。我们的目的是评估急性咖啡因摄入对完全睡眠剥夺（TSD）期间认知脆弱性和大脑活动的影响，并考虑习惯性咖啡因摄入。(2) 方法：37 名受试者在双盲、交叉、完全睡眠剥夺方案中接受咖啡因或安慰剂治疗进行评估。在 TSD 期间，每隔六小时使用脑电图记录的警觉性注意力测试（PVT）进行评估。通过将受试者分为低、中、高消费者来分析习惯性咖啡因摄入的影响。(3) 结果：PVT 反应时间（RT）在 TSD 期间增加，且咖啡因条件下的 RT 低于安慰剂条件。无论条件和治疗如何，低咖啡因消费者的 RT 均短于中、高咖啡因消费者。急性咖啡因摄入可独立于习惯性咖啡因摄入减轻 TSD 相关的 EEG 功率增加，并且高消费组的个体 alpha 频率（IAF）较低。IAF 与日间嗜睡呈负相关。此外，相关分析表明，每日咖啡因摄入量越高，RT 越高，IAF 越低。(4) 结论：高水平的习惯性咖啡因摄入会降低注意力表现和 alpha 频率，降低对睡眠剥夺的耐受性。
