Anderson J H, Blackard W G
Endocrinology. 1978 Jan;102(1):291-5. doi: 10.1210/endo-102-1-291.
Lithium exerts an inhibitory effect on glucose and amino acid-induced insulin release. The inhibitory effect of Li+ persists even in subsequent Li+-free conditions, indicating an only slowly reversible effect. Lithium fails to inhibit glucagon-induced insulin release. The exact mechanism of the lithium effect is as yet undetermined, but interference with calcium flux and/or microtubular function is an attractive hypothesis. The inhibitory effect of lithium on insulin release cannot be reversed by alteration in ionic (Ca++, Mg++, K+) concentrations in the incubation media. Studies involving the effect of low sodium on insulin release in which lithium had been used as an osmotic replacement for sodium must be carefully reassessed because of these findings.
锂对葡萄糖和氨基酸诱导的胰岛素释放具有抑制作用。即使在随后无锂的条件下，Li⁺的抑制作用仍然持续，这表明其作用只是缓慢可逆的。锂不能抑制胰高血糖素诱导的胰岛素释放。锂作用的确切机制尚未确定，但干扰钙通量和/或微管功能是一个有吸引力的假说。锂对胰岛素释放的抑制作用不能通过改变孵育介质中的离子（Ca²⁺、Mg²⁺、K⁺）浓度来逆转。鉴于这些发现，必须仔细重新评估那些使用锂作为钠的渗透替代物来研究低钠对胰岛素释放影响的研究。
