Chandrasekar B, Mathur S K, Mukherjee S K
Indian J Exp Biol. 1989 Feb;27(2):163-5.
Administration of lithium carbonate solution (50 mg/kg, po, twice daily) to Charles Foster male albino rats for 45 consecutive days caused an intolerance to oral glucose. Inhibition in (pro)insulin biosynthesis followed by a significant fall in immunoreactive insulin release was seen in islets isolated from identically treated rats. As the activities of acid phosphatase and cathepsin B were unaltered, it is possible that the anti-secretagogue effect is sequential to inhibition of (pro)insulin biosynthesis by lithium.
连续45天给雄性白化病查尔斯·福斯特大鼠口服碳酸锂溶液（50毫克/千克，每日两次），会导致其对口服葡萄糖不耐受。在从接受相同处理的大鼠分离出的胰岛中，观察到（前）胰岛素生物合成受到抑制，随后免疫反应性胰岛素释放显著下降。由于酸性磷酸酶和组织蛋白酶B的活性未改变，锂对（前）胰岛素生物合成的抑制作用可能是导致抗分泌作用的原因。
