Department of Biology and Environmental Sciences, Sefako Makgatho Health Sciences University, Pretoria 0204, South Africa.
Department of Health Science and The Water School, Florida Gulf Coast University, Fort Myers, FL 33965, USA.
Int J Environ Res Public Health. 2023 Mar 14;20(6):5133. doi: 10.3390/ijerph20065133.
Trace metals have been reported in the literature to be associated with obesity. Exposure to some trace metals such as Mn, Cr, Ni, Cd, and Pb may pose a serious health risk to individuals living around a polluted environment. The present study assessed the levels of trace metals in the blood of obese females living around industrial areas in Gauteng, South Africa. The study was carried out using a mixed method approach. Only females with a BMI ≥ 30.0 were considered. A total of 120 obese females participated in the study (site 1: 40-industrial area, site 2: 40-industrial area, and site 3: 40-residential area), aged 18-45 and not in menopause. Blood samples were analysed for trace metals content using inductively coupled plasma mass spectrometry (ICP-MS). The mean concentrations of trace metals were in the order Pb > Mn > Cr > Co > As > Cd (site 1), Pb > Mn > Co > As > Cd (site 2), and Mn > Cr > Co > As > Pb > Cd (site 3). The blood Mn from site 1 ranged from 6.79 µg/L-33.99 µg/L, and the mean differences obtained from the participants from different sites were significant ( < 0.01). The blood levels of Mn, Pb, Cr, Co, As, and Cd were above the recommended limits set by the WHO in some of the participants. The present study noted, among others, closeness to industrial areas, lifestyle decisions such as the use of tobacco products by their partners indoors, and the method used for cooking as factors that might have accounted for the blood levels of Mn, Pb, Cd and Co. The study showed that there is a need for constant monitoring of the levels of trace metals in the blood of those living in these areas.
已有文献报道，痕量金属与肥胖有关。暴露于某些痕量金属，如锰、铬、镍、镉和铅，可能会对生活在污染环境中的个体造成严重的健康风险。本研究评估了南非豪登省工业区周围肥胖女性血液中的痕量金属水平。该研究采用混合方法进行。仅考虑 BMI≥30.0 的女性。共有 120 名肥胖女性参与了这项研究（地点 1：40 个工业区，地点 2：40 个工业区，地点 3：40 个居民区），年龄在 18-45 岁之间且未绝经。使用电感耦合等离子体质谱法（ICP-MS）分析血液样本中的痕量金属含量。痕量金属的平均浓度顺序为 Pb＞Mn＞Cr＞Co＞As＞Cd（地点 1）、Pb＞Mn＞Co＞As＞Cd（地点 2）和 Mn＞Cr＞Co＞As＞Pb＞Cd（地点 3）。地点 1 的血液 Mn 浓度范围为 6.79µg/L-33.99µg/L，不同地点参与者的平均差异有统计学意义（<0.01）。一些参与者血液中的 Mn、Pb、Cr、Co、As 和 Cd 水平高于世界卫生组织（WHO）设定的推荐限值。本研究还指出，靠近工业区、室内使用烟草制品等生活方式决策以及烹饪方法等因素，可能是导致 Mn、Pb、Cd 和 Co 血液水平升高的原因。研究表明，需要对生活在这些地区的人群的血液中痕量金属水平进行持续监测。
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