Morales-Canton Virgilio, Meizner-Grezemkovsky Daniela, Baquero-Ospina Pablo, Crim Nicolás, Wu Lihteh
Retina Department, Asociación Para Evitar la Ceguera en México, "Hospital Dr. Luis Sanchez Bulnes", IAP, Mexico City 04030, Mexico.
Retina Department, Sanatorio del Salvador, Córdoba X5004, Argentina.
J Clin Med. 2023 Mar 17;12(6):2350. doi: 10.3390/jcm12062350.
In this paper, we compare the post-operative macular microvascular parameters (vascular density and foveal avascular zone) in eyes with refractory macular hole (MH) that underwent pars plana vitrectomy and autologous retinal transplant (ART) with the fellow unoperated eye. We conducted a retrospective case control study of six consecutive patients who underwent pars plana vitrectomy and ART with at least six months of post-operative follow-up. Pre-operatively, all eyes underwent SD-OCT (Spectral Domain Optical Coherence Tomography) examination. Post-operative OCT-A analyses included vascular density (VD) and the foveal avascular zone (FAZ) area. Six patients with a mean age of 63.7 ± 14.3 years were included. The mean follow-up was 24 months (range 6-30 months). The pre-operative BCVA (best-corrected visual acuity) was 0.99 ± 0.46 logMAR and 1.02 ± 0.23 logMAR at the last post-operative visit ( = 1.00). The mean MH diameter was 966 ± 620 µm. VD in the MH group was 28.1 ± 7.3% compared to 20.2 ± 2.9% in the fellow eyes group ( < 0.05). The mean post-operative FAZ area in the MH group was 109.8 ± 114.6 mm compared to 41.5 ± 10.4 mm in the control group ( < 0.05). In all six eyes, MH closure was obtained. The post-operative visual acuity did not improve after ART. Eyes with a closed MH showed a bigger FAZ with a higher VD compared to the fellow healthy eye.
在本文中，我们比较了接受玻璃体视网膜手术联合自体视网膜移植（ART）的难治性黄斑裂孔（MH）患眼与对侧未手术眼的术后黄斑微血管参数（血管密度和中心凹无血管区）。我们对连续6例接受玻璃体视网膜手术联合ART且术后随访至少6个月的患者进行了回顾性病例对照研究。术前，所有患眼均接受了频域光学相干断层扫描（SD-OCT）检查。术后光学相干断层扫描血管造影（OCT-A）分析包括血管密度（VD）和中心凹无血管区（FAZ）面积。纳入6例平均年龄为63.7±14.3岁的患者。平均随访时间为24个月（范围6 - 30个月）。术前最佳矫正视力（BCVA）为0.99±0.46 logMAR，术后最后一次随访时为1.02±0.23 logMAR（P = 1.00）。平均MH直径为966±620 µm。MH组的VD为28.1±7.3%，而对侧眼组为20.2±2.9%（P < 0.05）。MH组术后平均FAZ面积为·109.8±114.6 mm，而对照组为41.5±10.4 mm（P < 0.05）。所有6只患眼的MH均闭合。ART术后视力未改善。与对侧健康眼相比，MH闭合的患眼FAZ更大，VD更高。
