Ostensen M, Husby G, Mørland B
Clin Exp Immunol. 1986 Feb;63(2):434-40.
In a prospective study of pregnant patients with rheumatic disease and healthy pregnant women, the effect of pregnancy serum on human blood monocytes was investigated. Intracellular activity of the collagen degrading enzyme cathepsin B was found to be significantly depressed in monocyte cultures exposed to pregnancy and cord sera, independent of the presence or absence of an inflammatory state in the pregnant woman. Enzyme inhibition developed in a dose-dependent fashion over 3 days in culture. In contrast to cord and pregnancy sera, non-pregnant serum and serum from oral contraceptive users displayed enzyme stimulating activity. The response of monocytes to the stimulating agent carrageenan was unaffected by inhibitory sera. The nature of possible inhibitory factors in pregnancy and cord serum is discussed.
在一项针对患有风湿性疾病的孕妇和健康孕妇的前瞻性研究中，研究了妊娠血清对人血单核细胞的影响。发现在暴露于妊娠血清和脐带血清的单核细胞培养物中，胶原蛋白降解酶组织蛋白酶B的细胞内活性显著降低，这与孕妇是否存在炎症状态无关。在培养过程中，酶抑制作用在3天内呈剂量依赖性发展。与脐带血清和妊娠血清不同，非妊娠血清和口服避孕药使用者的血清表现出酶刺激活性。单核细胞对刺激剂角叉菜胶的反应不受抑制性血清的影响。文中讨论了妊娠血清和脐带血清中可能的抑制因子的性质。
