Wajner M, Papiha S S, Wagstaff T I
Clin Exp Immunol. 1983 May;52(2):381-6.
Peripheral blood lymphocytes were stimulated with various mitogens (PHA, Con A and PWM) and allogenic cells in the presence of cord serum. The cord sera suppressed more effectively certain T cell populations. This immunoregulatory response of cord serum was compared with nonpregnant and pregnant sera from different gestations. Although the cord sera showed significantly higher inhibition compared to normal adult serum but the serum from gravidae in late gestation proved more inhibitory compared to cord serum. No correlation was found between the levels of alpha-fetoprotein (AFP) in the cord sera and the degree of inhibition observed in the cultures. As previously described for pregnant sera the cord serum obtained from women with different numbers of pregnancies did not correlate with the inhibition of cellular proliferation. Our results suggest a possible different suppressor factor in pregnant and cord sera and also excludes the possibility of AFP in cord sera as a suppressor agent of cell-mediated immunity.
在脐血清存在的情况下，用各种有丝分裂原（PHA、Con A和PWM）及同种异体细胞刺激外周血淋巴细胞。脐血清能更有效地抑制某些T细胞群体。将脐血清的这种免疫调节反应与来自不同孕期的未孕和孕母血清进行了比较。虽然脐血清与正常成人血清相比显示出显著更高的抑制作用，但妊娠晚期孕妇的血清比脐血清的抑制作用更强。在脐血清中未发现甲胎蛋白（AFP）水平与培养物中观察到的抑制程度之间存在相关性。如先前对孕母血清所描述的那样，从不同妊娠次数的妇女获得的脐血清与细胞增殖的抑制无关。我们的结果提示，孕母血清和脐血清中可能存在不同的抑制因子，并且也排除了脐血清中的AFP作为细胞介导免疫抑制因子的可能性。
