Bednarova Aneta, Habalova Viera, Iannaccone Silvia Farkasova, Tkac Ivan, Jarcuskova Dominika, Krivosova Michaela, Marcatili Matteo, Hlavacova Natasa
2nd Department of Psychiatry, Faculty of Medicine, Pavol Jozef Safarik University, University Hospital of Louis Pasteur, 041 90 Kosice, Slovakia.
Department of Medical Biology, Faculty of Medicine, Pavol Jozef Safarik University, 040 11 Kosice, Slovakia.
J Pers Med. 2023 Mar 10;13(3):501. doi: 10.3390/jpm13030501.
Since suicide and suicidal behavior are considered highly heritable phenotypes, the identification of genetic markers that can predict suicide risk is a clinically important topic. Several genes studied for possible associations between genetic polymorphisms and suicidal behaviors had mostly inconsistent and contradictory findings. The aim of this case-control study was to evaluate the associations between completed suicide and polymorphisms in genes (rs6265, rs962369), (), and (rs9939609) in relation to sex and BMI. We genotyped 119 completed suicide victims and 137 control subjects that were age, sex, and ethnicity matched. A significant association with completed suicide was found for rs962369. This variant could play a role in completed suicide, as individuals with the CC genotype were more often found among suicides than in control subjects. After sex stratification, the association remained significant only in males. A nominally significant association between the gene variant and BMI was observed for rs962369 under the overdominant model. Heterozygotes with the TC genotype showed a lower average BMI than homozygotes with TT or CC genotypes. polymorphism (rs9939609) did not affect BMI in the group of Slovak suicide completers, but our findings follow an inverse association between BMI and completed suicide.
由于自杀和自杀行为被认为是高度可遗传的表型，因此识别能够预测自杀风险的遗传标记是一个具有临床重要性的课题。几项针对基因多态性与自杀行为之间可能存在的关联进行研究的基因，大多得出了不一致和相互矛盾的结果。本病例对照研究的目的是评估自杀死亡与基因（rs6265、rs962369）、（）和（rs9939609）的多态性之间与性别和体重指数（BMI）相关的关联。我们对119名自杀死亡受害者和137名年龄、性别和种族相匹配的对照者进行了基因分型。发现rs962369与自杀死亡存在显著关联。这种变异可能在自杀死亡中起作用，因为CC基因型个体在自杀者中比在对照者中更常见。按性别分层后，该关联仅在男性中仍具有显著性。在超显性模型下，观察到rs962369基因变异与BMI之间存在名义上的显著关联。TC基因型杂合子的平均BMI低于TT或CC基因型纯合子。多态性（rs9939609）在斯洛伐克自杀死亡者群体中不影响BMI，但我们的研究结果显示BMI与自杀死亡之间存在负相关。
