Raman Swarnalakshmi, Ikutame Daisuke, Okura Kazuo, Matsuka Yoshizo
Department of Stomatognathic Function and Occlusal Reconstruction, Graduate School of Biomedical Sciences, Tokushima University, Tokushima 770-8504, Japan.
J Pers Med. 2023 Mar 22;13(3):565. doi: 10.3390/jpm13030565.
Orofacial pain (OFP) is a dental specialty that includes the diagnosis, management and treatment of disorders of the jaw, mouth, face, head and neck. Evidence-based understanding is critical in effectively treating OFPs as the pathophysiology of these conditions is multifactorial. Since OFP impacts the quality of life of the affected individuals, treating patients successfully is of the utmost significance. Despite the therapeutic choices available, treating OFP is still quite challenging, owing to inter-patient variations. The emerging trends in precision medicine could probably lead us to a paradigm shift in effectively managing the untreatable long-standing pain conditions. Precision medicine is designed based on the patient's genetic profile to meet their needs. Several significant relationships have been discovered based on the genetics and genomics of pain in the past, and some of the notable targets are discussed in this review. The scope of this review is to discuss preclinical and clinical trials that include approaches used in targeted therapy for orofacial pain. Future developments in pain medicine should benefit from current trends in research into novel therapeutic approaches.
口腔颌面疼痛（OFP）是一个牙科专业领域，包括对颌骨、口腔、面部、头部和颈部疾病的诊断、管理及治疗。鉴于这些病症的病理生理学具有多因素性，基于证据的理解对于有效治疗口腔颌面疼痛至关重要。由于口腔颌面疼痛会影响患者的生活质量，成功治疗患者具有极其重要的意义。尽管有多种治疗选择，但由于患者个体差异，治疗口腔颌面疼痛仍然颇具挑战性。精准医学的新趋势可能会引领我们在有效管理难以治疗的长期疼痛病症方面实现范式转变。精准医学是根据患者的基因特征设计的，以满足他们的需求。过去基于疼痛的遗传学和基因组学已经发现了一些重要关系，本综述将讨论其中一些值得注意的靶点。本综述的范围是讨论临床前和临床试验，包括用于口腔颌面疼痛靶向治疗的方法。疼痛医学的未来发展应受益于当前新型治疗方法研究的趋势。
