Stan-Ilie Madalina, Şandru Vasile, Plotogea Oana-Mihaela, Rînja Ecaterina, Pavel Christopher, Constantinescu Gabriel, Negreanu Lucian, Paduraru Dan Nicolae, Bolocan Alexandra, Andronic Octavian, Davitoiu Dragos, Bălan Gheorghe G, Constantinescu Alexandru
Department of Gastroenterology, Clinical Emergency Hospital of Bucharest, 105402 Bucharest, Romania.
Department 5, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Life (Basel). 2023 Feb 21;13(3):597. doi: 10.3390/life13030597.
Duodenal gangliocytic paragangliomas are rare neuroendocrine tumors primarily localized in the periampullary area. Though mostly asymptomatic, they can present with various symptoms, most often jaundice, anemia and abdominal pain. The present paper is a case series report, describing our personal experience with patients presenting to the Emergency Unit with different symptoms due to duodenal gangliocytic paraganglioma. Endoscopic resection is safe and indicated in most of the cases, being also associated with lower medical costs. EUS plays a central role in the pre-resection management and in surveillance, and immunostaining is decisive to ascertain the tumor histologic origin. In addition to reporting our experience, we researched the literature regarding these rare tumors and performed a comprehensive review.
十二指肠神经节细胞性副神经节瘤是一种罕见的神经内分泌肿瘤，主要位于壶腹周围区域。尽管大多数情况下无症状，但它们可能会出现各种症状，最常见的是黄疸、贫血和腹痛。本文是一篇病例系列报告，描述了我们在急诊室遇到的因十二指肠神经节细胞性副神经节瘤而出现不同症状的患者的个人经验。内镜切除在大多数情况下是安全的且是首选的，同时还能降低医疗成本。超声内镜在切除前的管理和监测中起着核心作用，免疫染色对于确定肿瘤的组织学起源具有决定性意义。除了报告我们的经验外，我们还研究了有关这些罕见肿瘤的文献并进行了全面综述。
