Department of Ophthalmology, Faculty of Medical Sciences, University of Fukui, Fukui 910-1193, Japan.
Medicina (Kaunas). 2023 Feb 21;59(3):423. doi: 10.3390/medicina59030423.
: The purpose of this study was to evaluate the posture-induced intraocular pressure (IOP) changes after iStent inject W combined with phacoemulsification procedure in Japanese patients with open-angle glaucoma. : We prospectively evaluated the posture-induced IOP changes after surgery. The primary outcome was the posture-induced IOP changes postoperatively. Secondary outcome measures included postoperative complications, visual acuity, visual field, and corneal endothelial cell density. : This study completed the prospective observation for 15 eyes (15 patients). The mean preoperative IOP with the Goldmann applanation tonometer was 16.0 ± 2.6 mm Hg with a mean glaucoma medication usage of 2.5 ± 1.2, which decreased to 14.4 ± 2.4 mm Hg ( = 0.14) and 0.5 ± 0.9 medications ( < 0.01), respectively, 12 months postoperatively. The mean baseline IOP with the ICare was 12.0 ± 2.7 mmHg in the sitting position, which significantly increased to 15.2 ± 3.8 mmHg in the lateral decubitus position ( < 0.01). This postural IOP difference was 3.2 ± 2.2 mmHg and 3.2 ± 2.4 mmHg at baseline and 12 months postoperatively, respectively, with no significant changes ( > 0.99). : iStent inject W combined with cataract surgery reduced the IOP and the number of glaucoma medications during short-term follow-ups with high safety. However, iStent inject W did not affect the degree of posture-induced IOP changes.
本研究旨在评估 iStent inject W 联合超声乳化术治疗开角型青光眼日本患者术后体位性眼压（IOP）变化。
我们前瞻性评估了术后体位性IOP 变化。主要结局为术后体位性IOP 变化。次要结局指标包括术后并发症、视力、视野和角膜内皮细胞密度。
本研究对 15 只眼（15 例）完成了前瞻性观察。术前平均眼压（Goldmann 压平眼压计）为 16.0 ± 2.6mmHg，平均降眼压药物使用量为 2.5 ± 1.2，术后 12 个月分别降至 14.4 ± 2.4mmHg（=0.14）和 0.5 ± 0.9 种药物（<0.01）。坐位时 ICare 平均基础眼压为 12.0 ± 2.7mmHg，侧卧位时显著升高至 15.2 ± 3.8mmHg（<0.01）。这种体位性IOP 差值分别为 3.2 ± 2.2mmHg 和 3.2 ± 2.4mmHg，基线和术后 12 个月时分别为 3.2 ± 2.2mmHg 和 3.2 ± 2.4mmHg，无明显变化（>0.99）。
iStent inject W 联合白内障手术可降低眼压和降眼压药物的使用量，短期随访安全性高。然而，iStent inject W 对体位性IOP 变化程度无影响。
