Xu Dong, Pan Guangyao, Ge Yutong, Yang Xuan
National University of Singapore (Suzhou) Research Institute, Suzhou 215123, China.
Membranes (Basel). 2023 Mar 8;13(3):310. doi: 10.3390/membranes13030310.
The attainment of high-protein-retention and low-protein-fouling membranes is crucial for industries that necessitate protein production or separation process. The present study aimed to develop a novel method for preparing polyacrylonitrile (PAN) membranes possessing a highly hydrophilic and negatively charged surface as well as interior structure. The method involved a pre-hydrolysis treatment during the preparation of the PAN dope solution, followed by phase inversion in an alkaline solution. Chemical and material characterization of the dopes and membranes uncovered that the cyclized PAN structure served as a reaction intermediate that facilitated strong hydrolysis effect during phase inversion and homogeneously formed carboxyl groups in the membrane's interior structure. The resulting membrane showed a highly hydrophilic surface with a contact angle of 12.4° and demonstrated less than 21% flux decay and more than 95% flux recovery during multi-cycle filtration of bovine serum albumin (BSA) solution, with a high protein rejection rate of 96%. This study offers a facile and effective alternative for preparing PAN membranes with enhanced antifouling and protein-retention properties.
获得高蛋白质保留率和低蛋白质污染的膜对于需要蛋白质生产或分离过程的行业至关重要。本研究旨在开发一种制备具有高度亲水性和带负电荷表面以及内部结构的聚丙烯腈（PAN）膜的新方法。该方法包括在制备PAN铸膜液期间进行预水解处理，然后在碱性溶液中进行相转化。对铸膜液和膜的化学和材料表征发现，环化的PAN结构作为反应中间体，在相转化过程中促进了强烈的水解作用，并在膜的内部结构中均匀地形成了羧基。所得膜具有12.4°的接触角，表现出高度亲水性的表面，并且在牛血清白蛋白（BSA）溶液的多循环过滤过程中通量衰减小于21%，通量恢复率超过95%，蛋白质截留率高达96%。本研究为制备具有增强的抗污染和蛋白质保留性能的PAN膜提供了一种简便有效的替代方法。
