Glucose metabolism in the obese hyperglycaemic (C57B1/6 ob/ob) mouse: the effects of fasting on glucose turnover rates.

Rates of glucose turnover and of glucose-carbon recycling in fed and fasted C57B1/6 ob/ob mice were measured using D-[6(-3)H/U-14C]-glucose. In both the fed and fasted state, obese mice had significantly higher blood glucose concentrations than their lean littermates. This hyperglycaemia was a consequence of elevated rates of glucose synthesis and of glucose-lactate (Cori cycle) recycling.