用针对胎盘型碱性磷酸酶的123I标记单克隆抗体（H317）对上皮性卵巢肿瘤进行放射性核素显像。

Radionuclide imaging of epithelial ovarian tumours with 123I-labelled monoclonal antibody (H317) specific for placental-type alkaline phosphatase.

作者信息

Critchley M, Brownless S, Patten M, McLaughlin P J, Tromans P M, McDicken I W, Johnson P M

出版信息

Clin Radiol. 1986 Mar;37(2):107-12. doi: 10.1016/s0009-9260(86)80373-7.

Abstract

A murine monoclonal antibody, H317, specific for placental-type alkaline phosphatase was labelled with 123I and assessed as an imaging agent using a gamma camera computer system in 18 patients suspected of possible recurrent or metastatic ovarian cancer 1-4 years after removal of the primary tumour. Four patterns of distribution were visible: (1) normal uptake; (2) focal accumulation; (3) diffuse uptake; and (4) 'cold' areas. Six patients, five of whom were clinically negative for ovarian cancer, had normal scans; 11 patients, eight of whom were clinically positive, had increased uptake. One patient had visibly 'cold' areas. Findings were confirmed, where possible, at surgery.

摘要

一种针对胎盘型碱性磷酸酶的鼠单克隆抗体H317，用123I进行标记，并在18例怀疑可能患有复发性或转移性卵巢癌的患者中，使用γ相机计算机系统作为显像剂进行评估。这些患者在原发性肿瘤切除后1至4年。可见四种分布模式：（1）正常摄取；（2）局灶性聚集；（3）弥漫性摄取；（4）“冷”区。6例患者扫描结果正常，其中5例临床诊断为卵巢癌阴性；11例患者摄取增加，其中8例临床诊断为阳性。1例患者可见明显的“冷”区。在可能的情况下，手术结果证实了这些发现。