Shimada K, Kitazumi T, Ogura H, Sadakane N, Ozawa T
Clin Sci (Lond). 1986 May;70(5):489-94. doi: 10.1042/cs0700489.
Inter-relationship between age, systolic blood pressure and baroreflex sensitivity index derived from the Valsalva manoeuvre was investigated in either combined or separated groups of normal and hypertensive subjects. Both in the total population as a whole and in each blood pressure subgroup, the baroreflex sensitivity index was significantly inversely related to age and to systolic blood pressure. Furthermore, age was significantly related to systolic blood pressure except in the hypertensive group. Partial correlation analysis showed that, in the total and hypertensive population, the baroreflex sensitivity index was significantly related to age and systolic blood pressure independently of each other variable. In the normal group, however, the baroreflex sensitivity index was not related to systolic blood pressure after adjusting for the effect of age, but remained significantly related to age independently of systolic blood pressure. The estimates of relative effects of the two variables on baroreflex sensitivity by multiple regression analysis were consistent with these results. Thus a prevailing concept of the inhibitory effect of blood pressure on baroreflex function may be accurate exclusively in hypertensive patients, and baroreflex function appears to be more sensitive to age-related changes in this system than to those related to blood pressure level, particularly in non-hypertensive normal subjects.
在正常人和高血压患者的合并组或分组中，研究了年龄、收缩压与通过瓦尔萨尔瓦动作得出的压力反射敏感性指数之间的相互关系。在总体人群以及每个血压亚组中，压力反射敏感性指数均与年龄和收缩压呈显著负相关。此外，除高血压组外，年龄与收缩压显著相关。偏相关分析表明，在总体人群和高血压人群中，压力反射敏感性指数与年龄和收缩压相互独立显著相关。然而，在正常组中，调整年龄影响后，压力反射敏感性指数与收缩压无关，但与年龄仍显著相关，且与收缩压无关。通过多元回归分析对这两个变量对压力反射敏感性的相对影响估计与这些结果一致。因此，血压对压力反射功能具有抑制作用这一普遍概念可能仅在高血压患者中准确，并且压力反射功能似乎对该系统中与年龄相关的变化比对与血压水平相关的变化更敏感，尤其是在非高血压的正常受试者中。
