对抗真菌感染的抗体：研发策略与进展
Antibodies to Combat Fungal Infections: Development Strategies and Progress.
作者信息
Rabaan Ali A, Alfaraj Amal H, Alshengeti Amer, Alawfi Abdulsalam, Alwarthan Sara, Alhajri Mashael, Al-Najjar Amal H, Al Fares Mona A, Najim Mustafa A, Almuthree Souad A, AlShurbaji Sultan T, Alofi Fadwa S, AlShehail Bashayer M, AlYuosof Buthina, Alynbiawi Ahlam, Alzayer Suha A, Al Kaabi Nawal, Abduljabbar Wesam A, Bukhary Zakiyah A, Bueid Ahmed S
机构信息
Molecular Diagnostic Laboratory, Johns Hopkins Aramco Healthcare, Dhahran 31311, Saudi Arabia.
College of Medicine, Alfaisal University, Riyadh 11533, Saudi Arabia.
出版信息
Microorganisms. 2023 Mar 6;11(3):671. doi: 10.3390/microorganisms11030671.
The finding that some mAbs are antifungal suggests that antibody immunity may play a key role in the defense of the host against mycotic infections. The discovery of antibodies that guard against fungi is a significant advancement because it gives rise to the possibility of developing vaccinations that trigger protective antibody immunity. These vaccines might work by inducing antibody opsonins that improve the function of non-specific (such as neutrophils, macrophages, and NK cells) and specific (such as lymphocyte) cell-mediated immunity and stop or aid in eradicating fungus infections. The ability of antibodies to defend against fungi has been demonstrated by using monoclonal antibody technology to reconsider the function of antibody immunity. The next step is to develop vaccines that induce protective antibody immunity and to comprehend the mechanisms through which antibodies mediate protective effects against fungus.
一些单克隆抗体具有抗真菌作用这一发现表明，抗体免疫可能在宿主抵御真菌感染的防御中起关键作用。能够抵御真菌的抗体的发现是一项重大进展，因为这增加了开发能够触发保护性抗体免疫的疫苗的可能性。这些疫苗可能通过诱导抗体调理素发挥作用，抗体调理素可改善非特异性（如中性粒细胞、巨噬细胞和自然杀伤细胞）和特异性（如淋巴细胞）细胞介导免疫的功能，并阻止或协助根除真菌感染。利用单克隆抗体技术重新审视抗体免疫的功能，已经证明了抗体抵御真菌的能力。下一步是开发能够诱导保护性抗体免疫的疫苗，并了解抗体介导抗真菌保护作用的机制。
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