Volatile Metabolites of (Miq.) C.DC. from Northern Region of Colombia and Assessment of In Vitro Bioactivities of the Leaf Essential Oil.

is one of the species found in the Sierra Nevada de Santa Marta, and the species has been reported with different compositions of their essential oils (EO). In this study, the volatile fractions/essential oil (by HS-SPME/SDE/MWHD-GC-MS/H-NMR) of different parts from the plant were characterized, and assessments of the in vitro bio-properties of the leaf EO were conducted. The results indicated the following: (i) in the volatile fractions were β-caryophyllene (23%)/myrcene (20%) (inflorescences) and β-caryophyllene (43%)/β-selinene (20%) (leaves) using HS-SPME; myrcene (31%)/β-pinene (23%) (inflorescences), gibbilimbol B (60%) (fruits) and gibbilimbol B (46%)/β-caryophyllene (11%) (leaves) through SDE; (ii) leaf EO contained gibbilimbol B (72%), confirmed with H-NMR; (iii) the cytotoxic values (µg/mL) in erythrocytes/lymphocytes/Hep-2 were HC: 115 ± 3 (eryth.), LC: 71 ± 4 (lymph.) and LC: 33 ± 2 (cell-line); (iv) the antibacterial susceptibilities (ϕ inh. zone, mm; 4-16 µg EO) were 22.5 ± 0.4-97 ± 4 (), 23 ± 2-77 ± 4 () and 17 ± 1-48 ± 3 (); (v) the TAA value was 2249 ± 130 mmol Trolox/kg; (vi) the IC value was 13±1 µg/mL (AChE) with 20 ± 0-37 ± 6% repellency (2-4 h, ). Thus, the EO of leaves from northern Colombia could be a promising species for sustainable exploitation in the future due to its outstanding bioactivities.