Abd-Elsabour Mohamed, Abou-Krisha Mortaga M, Kenawy Sayed H, Yousef Tarek A
Chemistry Department, Faculty of Science, South Valley University, Qena 83523, Egypt.
Chemistry Department, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 11623, Saudi Arabia.
Nanomaterials (Basel). 2023 Mar 16;13(6):1079. doi: 10.3390/nano13061079.
A simple and eco-friendly electrochemical sensor for the anti-inflammatory diclofenac (DIC) was developed in a chitosan nanocomposite carbon paste electrode (M-Chs NC/CPE). The M-Chs NC/CPE was characterized with FTIR, XRD, SEM, and TEM for the size, surface area, and morphology. The produced electrode showed a high electrocatalytic activity to use the DIC in 0.1 M of the BR buffer (pH 3.0). The effect of scanning speed and pH on the DIC oxidation peak suggests that the DIC electrode process has a typical diffusion characteristic with two electrons and two protons. Furthermore, the peak current linearly proportional to the DIC concentration ranged from 0.025 M to 4.0 M with the correlation coefficient (r2). The sensitivity, limit of detection (LOD; 3σ), and the limit of quantification (LOQ; 10σ) were 0.993, 9.6 µA/µM cm, 0.007 µM, and 0.024 µM, respectively. In the end, the proposed sensor enables the reliable and sensitive detection of DIC in biological and pharmaceutical samples.
一种用于检测抗炎药物双氯芬酸（DIC）的简单且环保的电化学传感器，是在壳聚糖纳米复合碳糊电极（M-Chs NC/CPE）中开发的。通过傅里叶变换红外光谱（FTIR）、X射线衍射（XRD）、扫描电子显微镜（SEM）和透射电子显微镜（TEM）对M-Chs NC/CPE的尺寸、表面积和形态进行了表征。制备的电极在0.1 M的BR缓冲液（pH 3.0）中对DIC表现出高电催化活性。扫描速度和pH对DIC氧化峰的影响表明，DIC电极过程具有典型的双电子和双质子扩散特征。此外，峰电流与DIC浓度在0.025 M至4.0 M范围内呈线性比例关系，并具有相关系数（r2）。灵敏度、检测限（LOD；3σ）和定量限（LOQ；10σ）分别为0.993、9.6 μA/μM cm、0.007 μM和0.024 μM。最后，所提出的传感器能够可靠且灵敏地检测生物和药物样品中的DIC。
