Tejpal Singh Hashwin Singh, Aminuddin Alya Aqilah, Pang Kok-Lun, Ekeuku Sophia Ogechi, Chin Kok-Yong
Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, Malaysia.
Newcastle University Medicine Malaysia, Iskandar Puteri 79200, Malaysia.
Pharmaceuticals (Basel). 2023 Mar 2;16(3):385. doi: 10.3390/ph16030385.
Arthritis is a cluster of diseases impacting joint health and causing immobility and morbidity in the elderly. Among the various forms of arthritis, osteoarthritis (OA) and rheumatoid arthritis (RA) are the most common. Currently, satisfying disease-modifying agents for arthritis are not available. Given the pro-inflammatory and oxidative stress components in the pathogenesis of arthritis, tocotrienol, a family of vitamin E with both anti-inflammatory and antioxidant properties, could be joint-protective agents. This scoping review aims to provide an overview of the effects of tocotrienol on arthritis derived from the existing scientific literature. A literature search using PubMed, Scopus and Web of Science databases was conducted to identify relevant studies. Only cell culture, animal and clinical studies with primary data that align with the objective of this review were considered. The literature search uncovered eight studies investigating the effects of tocotrienol on OA = 4) and RA ( = 4). Most of the studies were preclinical and revealed the positive effects of tocotrienol in preserving joint structure (cartilage and bone) in models of arthritis. In particular, tocotrienol activates the self-repair mechanism of chondrocytes exposed to assaults and attenuates osteoclastogenesis associated with RA. Tocotrienol also demonstrated strong anti-inflammatory effects in RA models. The single clinical trial available in the literature showcases that palm tocotrienol could improve joint function among patients with OA. In conclusion, tocotrienol could be a potential anti-arthritic agent pending more results from clinical studies.
关节炎是一组影响关节健康并导致老年人行动不便和发病的疾病。在各种形式的关节炎中，骨关节炎（OA）和类风湿性关节炎（RA）最为常见。目前，尚无令人满意的用于治疗关节炎的病情改善药物。鉴于关节炎发病机制中存在促炎和氧化应激成分，生育三烯酚作为维生素E家族的一员，具有抗炎和抗氧化特性，可能是保护关节的药物。本综述旨在概述现有科学文献中生育三烯酚对关节炎的影响。通过使用PubMed、Scopus和Web of Science数据库进行文献检索，以确定相关研究。仅纳入了符合本综述目标的具有原始数据的细胞培养、动物和临床研究。文献检索发现了八项研究，其中四项研究生育三烯酚对骨关节炎的影响，四项研究对类风湿性关节炎的影响。大多数研究为临床前研究，揭示了生育三烯酚在关节炎模型中对保护关节结构（软骨和骨骼）的积极作用。特别是，生育三烯酚可激活遭受攻击的软骨细胞的自我修复机制，并减弱与类风湿性关节炎相关的破骨细胞生成。生育三烯酚在类风湿性关节炎模型中也表现出强大的抗炎作用。文献中现有的一项临床试验表明，棕榈生育三烯酚可改善骨关节炎患者的关节功能。总之，在获得更多临床研究结果之前，生育三烯酚可能是一种潜在的抗关节炎药物。
