Conte Miriam, De Feo Maria Silvia, Sidrak Marko Magdi Abdou, Corica Ferdinando, Gorica Joana, Filippi Luca, Schillaci Orazio, De Vincentis Giuseppe, Frantellizzi Viviana
Department of Radiological Sciences, Oncology and Anatomo-Pathology, Sapienza, University of Rome, 00161 Rome, Italy.
Department of Nuclear Medicine, Santa Maria Goretti Hospital, 04100 Latina, Italy.
Pharmaceutics. 2023 Mar 7;15(3):867. doi: 10.3390/pharmaceutics15030867.
Dendrimers are nanoscale-size polymers with a globular structure. They are composed of an internal core and branching dendrons with surface active groups which can be functionalized for medical applications. Different complexes have been developed for imaging and therapeutic purposes. This systematic review aims to summarize the development of newer dendrimers for oncological applications in nuclear medicine.
An online literature search was conducted on Pubmed, Scopus, Medline, Cochrane Library, and Web Of Science databases selecting published studies from January 1999 to December 2022. The accepted studies considered the synthesis of dendrimer complexes for oncological nuclear medicine imaging and therapy.
111 articles were identified; 69 articles were excluded because they did not satisfy the selection criteria. Thus, nine duplicate records were removed. The remaining 33 articles were included and selected for quality assessment.
Nanomedicine has led researchers to create novel nanocarriers with high affinity for the target. Dendrimers represent feasible imaging probes and therapeutic agents since, through the functionalization of external chemical groups and thanks to the possibility to carry pharmaceuticals, it can be possible to exploit different therapeutic strategies and develop a useful weapon for oncological treatments.
树枝状大分子是具有球状结构的纳米级聚合物。它们由一个内部核心和带有表面活性基团的分支树突组成，这些表面活性基团可进行功能化以用于医学应用。已经开发出了用于成像和治疗目的的不同复合物。本系统综述旨在总结新型树枝状大分子在核医学肿瘤学应用方面的进展。
在PubMed、Scopus、Medline、Cochrane图书馆和Web of Science数据库上进行在线文献检索，选择1999年1月至2022年12月发表的研究。纳入的研究涉及用于肿瘤核医学成像和治疗的树枝状大分子复合物的合成。
共识别出111篇文章；69篇文章因不符合选择标准而被排除。因此，去除了9条重复记录。其余33篇文章被纳入并选择进行质量评估。
纳米医学促使研究人员创造出对靶点具有高亲和力的新型纳米载体。树枝状大分子是可行的成像探针和治疗剂，因为通过外部化学基团的功能化以及由于能够携带药物，可以采用不同的治疗策略并开发出用于肿瘤治疗的有效武器。
