Retamozo Marcela H, Silva Christian C, Tamayose Cinthia I, Carvalho Juliana C S, Romoff Paulete, Fávero Oriana A, Ferreira Marcelo J P
Departamento de Botânica, Instituto de Biociências, Universidade de São Paulo, São Paulo 05508-090, SP, Brazil.
São Bernardo College, São Bernardo do Campo 09715-020, SP, Brazil.
Plants (Basel). 2023 Mar 10;12(6):1262. doi: 10.3390/plants12061262.
is one of the largest genera of Asteraceae and its species are used in folk medicine for several medicinal purposes due to the presence of bioactive compounds. We investigated the phytochemical composition of polar extracts of . Using chromatographic procedures, diterpenoids (-kaurenoic acid), flavonoids (hispidulin, eupafolin, isoquercitrin, quercitrin, biorobin, rutin, and vicenin-2), caffeic acid, and chlorogenic acid derivatives (5--caffeoylquinic acid and its methyl ester, 3,4-di--caffeoylquinic acid, 4,5-di--caffeoylquinic acid, and 3,5-di--caffeoylquinic acid and its methyl ester) were isolated from polar fractions and are described. The extract, polar fractions, and fifteen isolated compounds were evaluated in relation to radical scavenging activity using two assays. Chlorogenic acid derivatives and flavonols exhibited higher antioxidant effects, confirming that is an important source of phenolic compounds with antiradical properties.
是菊科最大的属之一，由于其含有生物活性化合物，其物种在民间医学中用于多种药用目的。我们研究了的极性提取物的植物化学成分。通过色谱方法，从极性馏分中分离出二萜类化合物（-贝壳杉烯酸）、黄酮类化合物（獐牙菜黄素、泽兰黄素、异槲皮苷、槲皮苷、生物罗宾、芦丁和异荭草苷-2）、咖啡酸和绿原酸衍生物（5--咖啡酰奎尼酸及其甲酯、3,4-二--咖啡酰奎尼酸、4,5-二--咖啡酰奎尼酸以及3,5-二--咖啡酰奎尼酸及其甲酯）并进行了描述。使用两种测定方法对提取物、极性馏分和十五种分离出的化合物的自由基清除活性进行了评估。绿原酸衍生物和黄酮醇表现出更高的抗氧化作用，证实了是具有抗自由基特性的酚类化合物的重要来源。
