Souza Flávia Roberta Monteiro, Silva Giovanna Melo Martins, Cadavid Cesar Orlando Muñoz, Lisboa Lucas Dos Santos, Silva Maylla Maria Correia Leite, Paiva Weslley Souza, Ferreira Marcelo José Pena, de Paula Oliveira Riva, Rocha Hugo Alexandre Oliveira
Laboratório de Biotecnologia de Polímeros Naturais (BIOPOL), Programa de Pós-graduação em Bioquímica e Biologia Molecular, Centro de Biociências, Federal University of Rio Grande do Norte-UFRN, Natal 59078-970, Brazil.
Laboratório de Genética Bioquímica (LGB), Programa de Pós-graduação em Biotecnologia, Centro de Biociências, Federal University of Rio Grande do Norte-UFRN, Natal 59078-970, Brazil.
Antioxidants (Basel). 2022 Sep 27;11(10):1913. doi: 10.3390/antiox11101913.
Obesity is a global public health problem that is associated with oxidative stress. One of the strategies for the treatment of obesity is the use of drugs; however, these are expensive and have numerous side effects. Therefore, the search for new alternatives is necessary. is used in Brazilian folk medicine for the treatment of obesity. Here, leaf extract (BT) showed antioxidant activity in seven in vitro tests, and it was not toxic to 3T3 murine fibroblasts or . Furthermore, BT reduces the intracellular amount of reactive oxygen species and increases survival. Moreover, these effects were not dependent on transcription factors. The inhibition of fat accumulation by BT in the model was also investigated. BT reduced lipid accumulation in animals fed diets without or with high amount of glucose. Furthermore, it was observed using RNA interference (iRNA) that BT depends on the transcription factor NHR-49 to exert its effect. Phytochemical analysis of BT revealed rutin, hyperoside, and 5-caffeoylquinic acid as the main BT components. Thus, these data demonstrate that BT has antioxidant and anti-obesity effects. However, further studies should be conducted to understand the mechanisms involved in its action.
肥胖是一个与氧化应激相关的全球性公共卫生问题。治疗肥胖的策略之一是使用药物；然而，这些药物价格昂贵且有许多副作用。因此，寻找新的替代方法很有必要。[某种植物]在巴西民间医学中用于治疗肥胖。在此，[该植物]叶提取物（BT）在七项体外试验中显示出抗氧化活性，并且对3T3小鼠成纤维细胞或[某种细胞]无毒。此外，BT减少了细胞内活性氧的量并提高了[某种细胞]的存活率。而且，这些作用不依赖于转录因子。还研究了BT在[某种动物]模型中对脂肪积累的抑制作用。BT减少了喂食不含或含有大量葡萄糖饮食的动物体内的脂质积累。此外，使用RNA干扰（iRNA）观察到BT发挥其作用依赖于转录因子NHR - 49。BT的植物化学分析表明芦丁、金丝桃苷和5 - 咖啡酰奎尼酸是BT的主要成分。因此，这些数据表明BT具有抗氧化和抗肥胖作用。然而，应该进行进一步的研究以了解其作用所涉及的机制。
