MacIntyre N R
Chest. 1986 May;89(5):677-83. doi: 10.1378/chest.89.5.677.
Pressure support ventilation (PSV) is a pressure assist form of mechanical ventilatory support that augments the patient's spontaneous inspiratory efforts with a clinician selected level of positive airway pressure. To understand the effects of PSV on respiratory function, experiments were performed on 15 stable patients requiring synchronized intermittent mandatory ventilation (SIMV), as well as on a mechanical model simulating these patients' ventilatory systems. In the clinical study, gas exchange, airway pressures, blood pressure and heart rate were measured while SIMV was replaced by enough PSV to approximate the baseline SIMV tidal volume (VT). Measurements were repeated while this PSV level was then reduced in three 5 cm H2O steps every 10 to 15 minutes. It was found that PSV was a reasonable form of mechanical ventilatory support in patients with spontaneous ventilatory drives. It improves patient comfort, reduces the patient's ventilatory work, and provides a more balanced pressure and volume change form of muscle work to the patient. The clinical significance of these properties during the weaning process remain to be determined.
压力支持通气（PSV）是一种机械通气支持的压力辅助形式，它通过临床医生选择的气道正压水平来增强患者的自主吸气努力。为了解PSV对呼吸功能的影响，对15名需要同步间歇指令通气（SIMV）的稳定患者以及模拟这些患者通气系统的机械模型进行了实验。在临床研究中，当用足够的PSV替代SIMV以接近基线SIMV潮气量（VT）时，测量气体交换、气道压力、血压和心率。在每10至15分钟以5 cm H2O的步长分三步降低该PSV水平时重复测量。结果发现，PSV是有自主通气驱动患者的一种合理的机械通气支持形式。它可提高患者舒适度，减少患者的通气功，并为患者提供更平衡的压力和容积变化形式的肌肉功。这些特性在撤机过程中的临床意义仍有待确定。
