Fu K P, Hetzel N, Hung P P, Gregory F J
Chemotherapy. 1986;32(2):166-72. doi: 10.1159/000238409.
Cefpiramide and cefoperazone alone and in combination with gentamicin were compared for therapeutic efficacy against pseudomonal infections in normal mice and in mice made neutropenic by administration of cyclophosphamide. Neutropenic mice were more susceptible to infection with Pseudomonas aeruginosa than normal mice. At all challenge doses, combination therapy with either cefpiramide-gentamicin or cefoperazone-gentamicin was more effective than that with a single agent. Therapy with the cefpiramide-gentamicin combination was significantly more active than that with the cefoperazone-gentamicin combination in protecting mice from fatal bacteremia. Pharmacokinetic studies in mice showed that cefpiramide attained a peak serum concentration of 12 micrograms/ml and a serum half-life of 40 min, which are higher than attained by cefoperazone with values of 4 micrograms/ml and 18 min. These factors may have caused the combined cefpiramide-gentamicin therapy to result in significantly improved survival rates in mice as well as in higher bactericidal titers than the cefoperazone-gentamicin combination. The results show that cefpiramide when combined with gentamicin is effective in treating serious infections with P. aeruginosa in neutropenic mice.
对头孢匹胺和头孢哌酮单独使用以及它们与庆大霉素联合使用时，针对正常小鼠和通过给予环磷酰胺导致中性粒细胞减少的小鼠体内假单胞菌感染的治疗效果进行了比较。中性粒细胞减少的小鼠比正常小鼠更容易感染铜绿假单胞菌。在所有攻击剂量下，头孢匹胺 - 庆大霉素或头孢哌酮 - 庆大霉素联合治疗比单一药物治疗更有效。在保护小鼠免受致命菌血症方面，头孢匹胺 - 庆大霉素联合治疗比头孢哌酮 - 庆大霉素联合治疗显著更有效。小鼠体内的药代动力学研究表明，头孢匹胺的血清峰值浓度达到12微克/毫升，血清半衰期为40分钟，高于头孢哌酮的4微克/毫升和18分钟。这些因素可能导致头孢匹胺 - 庆大霉素联合治疗使小鼠的存活率显著提高，并且杀菌效价比头孢哌酮 - 庆大霉素联合治疗更高。结果表明，头孢匹胺与庆大霉素联合使用对治疗中性粒细胞减少小鼠的严重铜绿假单胞菌感染有效。
