Fu K P, Hetzel N, Gregory F J, Hung P P
Microbiology Division, Wyeth Laboratories, Inc., Philadelphia, PA 19101.
J Antimicrob Chemother. 1987 Oct;20(4):541-6. doi: 10.1093/jac/20.4.541.
The therapeutic efficacy of cefpiramide and ciprofloxacin alone and in combination was investigated and compared with that of ticarcillin plus tobramycin against pseudomonal infections in mice made neutropenic by administration of cyclosphosphamide. Therapy with cefpiramide plus ciprofloxacin was significantly more effective than that by either antibiotic alone. These results were consistent with in-vitro synergistic effects. At a higher dose of ciprofloxacin (4 mg/kg) plus cefpiramide (50 mg/kg), the combination therapy protected all neutropenic mice from fatal bacteraemia, and was more protective than ticarcillin (200 mg/kg) plus tobramycin (1 mg/kg). The peak serum concentration of cefpiramide in infected neutropenic mice was 51 mg/l when they were given 50 mg/kg subcutaneously. Ciprofloxacin attained a peak serum concentration of 1.2 mg/l and a serum half-life of 34 min.
研究了头孢匹胺和环丙沙星单独及联合用药的治疗效果，并将其与替卡西林加妥布霉素对通过给予环磷酰胺造成中性粒细胞减少的小鼠的假单胞菌感染的治疗效果进行了比较。头孢匹胺加环丙沙星联合治疗明显比单独使用任何一种抗生素更有效。这些结果与体外协同作用一致。在较高剂量的环丙沙星（4毫克/千克）加头孢匹胺（50毫克/千克）时，联合治疗保护所有中性粒细胞减少的小鼠免于致命菌血症，并且比替卡西林（200毫克/千克）加妥布霉素（1毫克/千克）更具保护作用。当感染的中性粒细胞减少的小鼠皮下给予50毫克/千克时，头孢匹胺的血清峰值浓度为51毫克/升。环丙沙星达到的血清峰值浓度为1.2毫克/升，血清半衰期为34分钟。
