Śmigiel-Gac Natalia, Smola-Dmochowska Anna, Janeczek Henryk, Dobrzyński Piotr
Centre of Polymer and Carbon Materials, Polish Academy of Sciences, 41-819 Zabrze, Poland.
Faculty of Science and Technology, Jan Długosz University in Czestochowa, 13/15 Armii Krajowej Av., 42-200 Czestochowa, Poland.
Polymers (Basel). 2023 Mar 16;15(6):1473. doi: 10.3390/polym15061473.
The article presents the results of the synthesis and characteristics of the amphiphilic block terpolymers, built of a hydrophilic polyesteramine block, and hydrophobic blocks made of lactidyl and glycolidyl units. These terpolymers were obtained during the copolymerization of L-lactide with glycolide carried out in the presence of previously produced macroinitiators with protected amine and hydroxyl groups. The terpolymers were prepared to produce a biodegradable and biocompatible material containing active hydroxyl and/or amino groups, with strong antibacterial properties and high surface wettability by water. The control of the reaction course, the process of deprotection of functional groups, and the properties of the obtained terpolymers were made based on H NMR, FTIR, GPC, and DSC tests. Terpolymers differed in the content of amino and hydroxyl groups. The values of average molecular mass oscillated from about 5000 g/mol to less than 15,000 g/mol. Depending on the length of the hydrophilic block and its composition, the value of the contact angle ranged from 50° to 20°. The terpolymers containing amino groups, capable of forming strong intra- and intermolecular bonds, show a high degree of crystallinity. The endotherm responsible for the melting of L-lactidyl semicrystalline regions appeared in the range from about 90 °C to close to 170 °C, with a heat of fusion from about 15 J/mol to over 60 J/mol.
本文介绍了两亲性嵌段三元共聚物的合成结果及其特性，该共聚物由亲水性聚酯胺嵌段以及由丙交酯基和乙交酯基单元组成的疏水性嵌段构成。这些三元共聚物是在L-丙交酯与乙交酯的共聚过程中获得的，该共聚反应是在预先制备的带有保护胺基和羟基的大分子引发剂存在下进行的。制备这些三元共聚物是为了生产一种含有活性羟基和/或氨基的可生物降解且生物相容的材料，该材料具有很强的抗菌性能和高的水表面润湿性。基于核磁共振氢谱（H NMR）、傅里叶变换红外光谱（FTIR）、凝胶渗透色谱（GPC）和差示扫描量热法（DSC）测试对反应过程、官能团脱保护过程以及所得三元共聚物的性能进行了控制。三元共聚物的氨基和羟基含量不同。平均分子量的值在约5000 g/mol至小于15000 g/mol之间波动。根据亲水性嵌段的长度及其组成，接触角的值在50°至20°之间。含有能够形成强分子内和分子间键的氨基的三元共聚物表现出高度的结晶度。负责L-丙交酯基半结晶区域熔化的吸热峰出现在约90°C至接近170°C的范围内，熔化热在约15 J/mol至超过60 J/mol之间。
