Hagdrup H K, Lange Wantzin G, Secher L, Rosdahl V T
Chemotherapy. 1986;32(2):99-101. doi: 10.1159/000238397.
Twelve patients with syphilis were treated weekly with injections of 1.44 g (2.4 X 10(6) IU) of benzathine penicillin G for up to 3 weeks. Almost daily, serum penicillin concentrations were measured by a sensitive microbiological agar cup method. An individual and interindividual variation was found. Concentrations below the recommended 0.018 micrograms/ml were found 7 days after the first or second injection in 5 samples. Shorter intervals between injections are recommended.
12例梅毒患者每周接受苄星青霉素G 1.44 g（2.4×10⁶IU）注射治疗，疗程长达3周。几乎每天都通过灵敏的微生物琼脂杯法测定血清青霉素浓度。发现了个体间和个体内的差异。在5份样本中，首次或第二次注射后7天发现浓度低于推荐的0.018微克/毫升。建议缩短注射间隔时间。
