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半胱氨酸及其衍生物、谷胱甘肽辅酶A和二氢硫辛酸与异硫氰酸酯的反应。

Reactions of cysteine, its derivatives, glutathione coenzyme A, and dihydrolipoic acid with isothiocyanates.

作者信息

Podhradský D, Drobnica L, Kristian P

出版信息

Experientia. 1979 Feb 15;35(2):154-5. doi: 10.1007/BF01920581.

DOI:10.1007/BF01920581
PMID:369877
Abstract

Isothiocyanates react with deprotonated SH groups of investigated compounds to give the esters of N-monosubstituted dithiocarbamic acid. In the presence of the SH and NH2 groups (Cys, GSH), isothiocyanates react primarily with the SH groups. The reactions are dependent on the pKa SH values.

摘要

异硫氰酸酯与被研究化合物的去质子化巯基反应，生成N-单取代二硫代氨基甲酸酯。在存在巯基和氨基（半胱氨酸、谷胱甘肽）的情况下，异硫氰酸酯主要与巯基反应。这些反应取决于巯基的pKa值。

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本文引用的文献

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A note on the combination of cysteine with allyl isothiocyanate.关于半胱氨酸与烯丙基异硫氰酸酯结合的注释
Biochem J. 1937 Feb;31(2):297-8. doi: 10.1042/bj0310297.
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Determination of the microscopic ionization constants of cysteine.半胱氨酸微观电离常数的测定
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异硫氰酸苄酯诱导人前列腺癌细胞中活性氧引发的自噬和凋亡。
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Cruciferous vegetables, isothiocyanates, and prevention of bladder cancer.十字花科蔬菜、异硫氰酸盐与膀胱癌的预防
Curr Pharmacol Rep. 2015 Aug;1(4):272-282. doi: 10.1007/s40495-015-0024-z.
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Sulforaphane inhibits multiple inflammasomes through an Nrf2-independent mechanism.萝卜硫素通过一种不依赖Nrf2的机制抑制多种炎性小体。
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Insights into the mode of action of benzyl isothiocyanate on Campylobacter jejuni.解析苄基异硫氰酸酯对空肠弯曲杆菌作用方式的研究。
Appl Environ Microbiol. 2013 Nov;79(22):6958-68. doi: 10.1128/AEM.01967-13. Epub 2013 Sep 6.
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Antimicrobial activities of isothiocyanates against Campylobacter jejuni isolates.异硫氰酸酯对空肠弯曲菌分离株的抗菌活性。
Front Cell Infect Microbiol. 2012 Apr 20;2:53. doi: 10.3389/fcimb.2012.00053. eCollection 2012.
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The molecular basis that unifies the metabolism, cellular uptake and chemopreventive activities of dietary isothiocyanates.统一饮食中异硫氰酸盐的代谢、细胞摄取和化学预防活性的分子基础。
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Identification of potential protein targets of isothiocyanates by proteomics.采用蛋白质组学技术鉴定异硫氰酸酯的潜在蛋白靶点。
Chem Res Toxicol. 2011 Oct 17;24(10):1735-43. doi: 10.1021/tx2002806. Epub 2011 Aug 26.
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Proteins as binding targets of isothiocyanates in cancer prevention.异硫氰酸盐在癌症预防中的作用靶点——蛋白质。
Carcinogenesis. 2011 Oct;32(10):1405-13. doi: 10.1093/carcin/bgr111. Epub 2011 Jun 10.