半胱氨酸及其衍生物、谷胱甘肽辅酶A和二氢硫辛酸与异硫氰酸酯的反应。
Reactions of cysteine, its derivatives, glutathione coenzyme A, and dihydrolipoic acid with isothiocyanates.
作者信息
Podhradský D, Drobnica L, Kristian P
出版信息
Experientia. 1979 Feb 15;35(2):154-5. doi: 10.1007/BF01920581.
PMID:369877
Abstract
Isothiocyanates react with deprotonated SH groups of investigated compounds to give the esters of N-monosubstituted dithiocarbamic acid. In the presence of the SH and NH2 groups (Cys, GSH), isothiocyanates react primarily with the SH groups. The reactions are dependent on the pKa SH values.
摘要
异硫氰酸酯与被研究化合物的去质子化巯基反应，生成N-单取代二硫代氨基甲酸酯。在存在巯基和氨基（半胱氨酸、谷胱甘肽）的情况下，异硫氰酸酯主要与巯基反应。这些反应取决于巯基的pKa值。
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