Danevska Ivana Arnaudova, Jakjovska Tatjana, Zendelovska Dragica, Atanasovska Emilija, Dzekova-Vidimliski Pavlina, Petrushevska Marija, Boshkovska Katerina, Popova Gorica, Tasevska Elena Gjinovska, Balkanov Trajan
1University of Ss Cyril and Methodius, Faculty of Medicine, Institute for Respiratory Diseases in Children, Skopje, RN Macedonia.
2University of Ss Cyril and Methodius, Faculty of Medicine, Institute of Preclinical and Clinical Pharmacology and Toxicology, Skopje, RN Macedonia.
Pril (Makedon Akad Nauk Umet Odd Med Nauki). 2023 Mar 29;44(1):17-26. doi: 10.2478/prilozi-2023-0003. Print 2023 Mar 1.
: Allergic rhinitis (AR) is characterized by chronic inflammation of the nasal mucosa. Under the influence of exogenous factors - allergens, reactive oxygen species (ROS) are released during cellular metabolism. They induce a series of pathological changes in the mucosa. Oxidative stress is а result of an imbalance between the production of ROS and the ability to neutralize them. The aim of this study is to compare the levels of oxidative stress between healthy children and children with allergic rhinitis. : A total number of 60 children were included (30 healthy children and 30 children with AR). The oxidative stress index was determined by using the FRAS 5 (Free Radical Analytical System) Bravo system. Demographic characteristics, medical history, children's living conditions and eating habits were obtained from the questionnaire. Anthropometric measurements and the absolute number of eosinophils in the peripheral smear were performed on each child. : This study showed high oxidative stress index and a significantly higher value of the absolute number of eosinophils in the peripheral smear in children with AR in comparison to healthy children (p<0.05). The group of children with AR had more atopic characteristics and was more exposed to passive smoking than healthy children. : Compared to healthy children, children with AR have a high index of oxidative stress, despite of the very high mean value of the concentration of water-soluble antioxidants in serum (PAT test) in the group of children with AR.
变应性鼻炎（AR）的特征是鼻黏膜慢性炎症。在外源性因素——变应原的影响下，细胞代谢过程中会释放活性氧（ROS）。它们会诱导黏膜发生一系列病理变化。氧化应激是ROS产生与中和能力失衡的结果。本研究的目的是比较健康儿童和变应性鼻炎患儿的氧化应激水平。
共纳入60名儿童（30名健康儿童和30名AR患儿）。使用FRAS 5（自由基分析系统）Bravo系统测定氧化应激指数。通过问卷获取人口统计学特征、病史、儿童生活条件和饮食习惯。对每个儿童进行人体测量和外周血涂片嗜酸性粒细胞绝对计数。
本研究表明，与健康儿童相比，AR患儿的氧化应激指数较高，外周血涂片嗜酸性粒细胞绝对计数的值显著更高（p<0.05）。AR患儿组比健康儿童有更多的特应性特征，且更多地暴露于被动吸烟环境。
与健康儿童相比，尽管AR患儿组血清中水溶性抗氧化剂浓度（PAT试验）的平均值非常高，但AR患儿的氧化应激指数仍较高。
