Department of Obstetrics and Gynaecology, Royal Women's Hospital, University of Melbourne, Melbourne, VIC, Australia.
Centre for Biostatistics, The University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom.
Hum Fertil (Camb). 2023 Dec;26(2):347-354. doi: 10.1080/14647273.2023.2191222. Epub 2023 Mar 29.
Trials evaluating the efficacy of IVF and various treatment options often focus on upstream outcome measures, improvements which may not translate into clinical outcome improvements. A cross-sectional online survey was distributed globally among IVF patients. Respondents were randomised to view one of 16 statements about a hypothetical IVF treatment option called 'FertiSure', stated to improve one of four upstream outcomes. Statements varied in whether they contained information stating that FertiSure was not proven to improve live-birth rates and about potential risks. Many patients inferred that improvements in upstream outcomes would result in improvements in the probability of live-birth. Nearly 80% of respondents were willing to use FertiSure. Respondents told that FertiSure was not proven to improve live-birth rates and were less willing to use FertiSure. More respondents agreed that FertiSure may pose a risk to patients when they were told this was the case. However, this did not affect their willingness to use FertiSure. Interestingly, 34% of respondents believed FertiSure would not improve the probability of live-birth but were still willing to use it. These results have implications for IVF clinic websites and information about treatment options which may not routinely contain statements about the limited evidence-base and possible risks.
评估 IVF 和各种治疗选择疗效的试验通常侧重于上游结果指标，这些改善可能不会转化为临床结果的改善。一项横断面在线调查在全球范围内向 IVF 患者进行。受访者被随机分配查看关于一种名为“FertiSure”的假设 IVF 治疗选择的 16 条陈述之一，该选择据称可以改善四个上游结果之一。陈述的内容各不相同，有些陈述包含 FertiSure 尚未证明可以提高活产率的信息，以及有关潜在风险的信息。许多患者推断，上游结果的改善将导致活产率提高的可能性增加。近 80%的受访者表示愿意使用 FertiSure。当告知 FertiSure 尚未证明可以提高活产率时，受访者的使用意愿降低。当告知 FertiSure 可能对患者构成风险时，更多的受访者表示同意。然而，这并没有影响他们使用 FertiSure 的意愿。有趣的是，34%的受访者认为 FertiSure 不会提高活产率的可能性，但仍愿意使用它。这些结果对 IVF 诊所的网站和有关治疗选择的信息具有启示意义，因为这些信息通常不包含有关有限证据基础和可能风险的陈述。
