氧化还原中性自由基接力镍催化远程羰基化反应
Redox Neutral Radical-Relay Nickel-Catalyzed Remote Carbonylation.
作者信息
Li Ming, Gao Fan, Miao Dong-Yu, Chen Dong-Ping, Li Shun-Xi, Qiu Yi-Feng, Quan Zheng-Jun, Wang Xi-Cun, Liang Yong-Min
机构信息
College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, Gansu 730070, P. R. China.
State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P. R. China.
出版信息
Org Lett. 2023 Apr 7;25(13):2306-2311. doi: 10.1021/acs.orglett.3c00654. Epub 2023 Mar 29.
A novel and efficient method for the catalytic installation of a carbonyl group via remote radical coupling is disclosed. The nickel-catalyzed reaction proceeds to undergo a sequential single-electron transfer, 1,5-hydrogen atom transfer, and carbonyl insertion, thus providing the α-substituted ketone. Further, this reaction could be carried out smoothly under normal pressure and redox-neutral conditions, and demonstrated functional-group compatibility and excellent site-selectivity.
公开了一种通过远程自由基偶联催化安装羰基的新颖且高效的方法。镍催化的反应依次进行单电子转移、1,5-氢原子转移和羰基插入，从而得到α-取代酮。此外，该反应可以在常压和氧化还原中性条件下顺利进行，并表现出官能团兼容性和出色的位点选择性。
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