虫草素预处理对小鼠肝缺血/再灌注损伤的保护作用。
Protective effects of cordycepin pretreatment against liver ischemia/reperfusion injury in mice.
机构信息
Department of Anesthesiology, Tianjin First Central Hospital, Tianjin, China.
出版信息
Immun Inflamm Dis. 2023 Mar;11(3):e792. doi: 10.1002/iid3.792.
INTRODUCTION
Cordycepin has been reported to exhibit hepatic protective and anti-inflammatory properties. Here, we investigated the role of cordycepin in ischemia/reperfusion (IR)-induced liver injury in a mouse model.
METHODS
Mice were pretreated with cordycepin by gavage for 3 weeks, followed by the establishment of the IR modeling. Liver injury, Suzuki's histological grading, hepatic apoptosis, and inflammatory responses were evaluated by biochemical and pathological analysis.
RESULTS
It was found that Cordycepin pretreatment at 50 mg/kg for 3 weeks attenuated IR-induced liver injury, as reflected by the significant decrease of the levels of aspartate aminotransferase, alanine transaminase, lactate dehydrogenase, and low-density lipoprotein. Cordycepin pretreatment also reduced histopathological changes, attenuated hepatocyte apoptosis, inflammatory responses in the livers of IR mice. Mechanically, toll-like receptor 4/nuclear factor kappa-B signaling in liver tissues was inhibited by Cordycepin pretreatment.
CONCLUSIONS
In conclusion, Cordycepin pretreatment protects IR-induced liver injury, which demonstrates its potential for the treatment of IR in the liver.
简介
蛹虫草素有肝保护和抗炎作用。在这里，我们研究了蛹虫草素在小鼠模型中缺血/再灌注（IR）诱导的肝损伤中的作用。
方法
通过灌胃预处理小鼠蛹虫草素 3 周，然后建立 IR 模型。通过生化和病理分析评估肝损伤、 Suzuki 组织学分级、肝凋亡和炎症反应。
结果
发现蛹虫草素预处理 50mg/kg 3 周可减轻 IR 引起的肝损伤，表现为天冬氨酸转氨酶、丙氨酸转氨酶、乳酸脱氢酶和低密度脂蛋白水平显著降低。蛹虫草素预处理还减轻了 IR 小鼠肝脏的组织病理学变化，减轻了肝实质细胞凋亡和炎症反应。机制上，蛹虫草素预处理抑制了肝组织中 Toll 样受体 4/核因子 kappa-B 信号通路。
结论
综上所述，蛹虫草素预处理可保护 IR 诱导的肝损伤，表明其在治疗肝脏 IR 方面具有潜力。
Zotero 插件