Department of Emergency, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, P.R. China.
Department of Pathology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, P.R. China.
Mol Med Rep. 2018 May;17(5):6675-6680. doi: 10.3892/mmr.2018.8709. Epub 2018 Mar 9.
The aim of the present study was to investigate the protective mechanisms and identify the effects of isoquercetin on myocardial infarction in a rat model of acute myocardial infarction (AMI). Isoquercetin ameliorated myocardial infarct size, creatine kinase (CK), CK‑MB and lactic dehydrogenase activity and inhibited inflammation, oxidative stress and heart cell apoptosis in a rat with AMI. Isoquercetin increased endothelial nitric oxide synthase, reduced inducible nitric oxide synthase levels and suppressed the Toll-like receptor 4‑nuclear factor (TLR4‑NF)‑κB signaling pathway in a rat with AMI. Overall, isoquercetin ameliorated AMI through anti‑inflammatory and anti‑apoptotic factors, and regulation of the TLR4‑NF‑κB signaling pathway. Isoquercetin may therefore potentially exert a protective effect against AMI or other heart diseases.
本研究旨在探讨槲皮素在急性心肌梗死（AMI）大鼠模型中对心肌梗死的保护机制和作用。槲皮素可改善 AMI 大鼠的心肌梗死面积、肌酸激酶（CK）、CK-MB 和乳酸脱氢酶活性，并抑制炎症、氧化应激和心肌细胞凋亡。槲皮素可增加内皮型一氧化氮合酶，降低诱导型一氧化氮合酶水平，并抑制 AMI 大鼠中 Toll 样受体 4-核因子（TLR4-NF）-κB 信号通路。综上所述，槲皮素通过抗炎和抗凋亡因子以及调节 TLR4-NF-κB 信号通路来改善 AMI。因此，槲皮素可能对 AMI 或其他心脏病具有潜在的保护作用。
