手性氰化丙炔 C-H 键的对映选择性 光氧化还原和铜催化协同作用。
Enantioselective cyanation of propargylic C-H bonds cooperative photoredox and copper catalysis.
机构信息
Department of Chemistry, University of Science and Technology of China, Hefei, 230026, China.
State Key Laboratory of Organometallic Chemistry, and Shanghai Hongkong Joint Laboratory in Chemical Synthesis, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200032, China.
出版信息
Chem Commun (Camb). 2023 Apr 13;59(31):4656-4659. doi: 10.1039/d3cc00410d.
Herein, we report an enantioselective cyanation of propargylic C-H bonds by combining photoredox catalysis with a copper-catalyzed radical relay in which the propargylic radical was generated by an intramolecular 1,5-HAT process. This reaction provides easy access to optically pure propargyl nitrile compounds under mild conditions.
在此，我们报告了一种通过光氧化还原催化与铜催化的自由基接力相结合的方法，实现了丙炔 C-H 键的对映选择性氰化反应，其中丙炔自由基是通过分子内 1,5-HAT 过程生成的。该反应在温和条件下为获得光学纯丙炔腈化合物提供了一种简便的方法。
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