Oxford Eye Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
Nuffield Laboratory of Ophthalmology, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Graefes Arch Clin Exp Ophthalmol. 2023 Aug;261(8):2257-2264. doi: 10.1007/s00417-023-06032-1. Epub 2023 Mar 29.
To demonstrate different topographic distributions of multiple-evanescent white dot syndrome (MEWDS) and secondary MEWDS disease and to describe possible associations.
Clinical evaluation and multimodal retinal imaging in 27 subjects with MEWDS (29 discrete episodes of MEWDS). Ophthalmic assessment included best-corrected visual acuity testing and multimodal retinal imaging with OCT, blue-light autofluorescence, fluorescein and indocyanine green angiography, fundus photography, and widefield pseudocolor and autofluorescence fundus imaging.
The topographic distribution of MEWDS lesions was centered on or around the optic disc (n = 17, 59%), centered on the macula (n = 7, 24%), sectoral (n = 2, 7%), or was indeterminate (n = 3, 10%). The MEWDS episodes either occurred in the absence ('primary MEWDS'; n = 14, 48%) or presence of concurrent chorioretinal pathology ('secondary MEWDS'; n = 15, 52%). In patients with the latter, MEWDS lesions were often centered around a coexisting chorioretinal lesion. The majority of patients in both groups experienced resolution of their symptoms and retinal changes on multimodal imaging by 3 months.
Distinct distributions of MEWDS lesions were identified. MEWDS may occur in tandem with other chorioretinal pathology, which may impact the topography of MEWDS lesions.
展示多发性一过性白点综合征（MEWDS）和继发黄斑区白点综合征（secondary MEWDS）的不同病变分布，并描述可能的关联。
对 27 名 MEWDS 患者（29 次离散性 MEWDS 发作）进行临床评估和多模态视网膜成像。眼科评估包括最佳矫正视力测试和多模态视网膜成像，包括 OCT、蓝光自发荧光、荧光素和吲哚菁绿血管造影、眼底照相以及广角假彩色和自发荧光眼底成像。
MEWDS 病变的病变分布集中在视盘（n=17，59%）、黄斑（n=7，24%）、扇形（n=2，7%）或不确定（n=3，10%）。MEWDS 发作要么发生在没有（“原发性 MEWDS”；n=14，48%）或存在同时的脉络膜视网膜病变（“继发性 MEWDS”；n=15，52%）的情况下。在后一组患者中，MEWDS 病变常集中在并存的脉络膜视网膜病变周围。两组患者的大多数在 3 个月时通过多模态成像，其症状和视网膜变化均得到缓解。
确定了 MEWDS 病变的不同分布。MEWDS 可能与其他脉络膜视网膜病变同时发生，这可能会影响 MEWDS 病变的分布。
