Pashintseva L P, Barlova M V, Bassalyk L S
Eksp Onkol. 1986;8(2):51-4.
The activity and isoenzyme spectrum of creatine kinase (CK) were studied in cytosole fraction 60 of the mammary gland carcinoma (MGC) and in the corresponding unchanged tissues. The values of the CK activity in MGC were found to be highly different (0.05-14.6 unit/g of tissue). The correlation of CK activity in MGC with the menstrual function was revealed. Enhancement in the CK activity is due to an increase in the BB-isoenzyme activity and an appearance of atypical supplementary MM1-isoenzyme is, possibly, of mitochondrial origin. These isoenzymes may be nonspecific markers of malignancy and may be used for diagnosis of mammary gland carcinoma.
研究了乳腺癌（MGC）细胞溶质部分60及相应未病变组织中肌酸激酶（CK）的活性和同工酶谱。发现MGC中CK活性值差异很大（0.05 - 14.6单位/克组织）。揭示了MGC中CK活性与月经功能的相关性。CK活性增强是由于BB同工酶活性增加以及出现可能源自线粒体的非典型补充MM1同工酶。这些同工酶可能是恶性肿瘤的非特异性标志物，可用于乳腺癌的诊断。
