乳腺癌患者血清肌酸激酶水平降低：病例对照研究。
Low serum creatine kinase levels in breast cancer patients: a case-control study.
机构信息
Department of Breast Surgery, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
出版信息
PLoS One. 2013 Apr 15;8(4):e62112. doi: 10.1371/journal.pone.0062112. Print 2013.
BACKGROUND
Previous studies provide an ambiguous picture of creatine kinase (CK) expression and activities in malignancy. The aim of this study was to investigate the role of serum CK level in breast cancer patients.
PATIENTS AND METHODS
823 female patients diagnosed with breast cancer were consecutively recruited as cases, and 823 age-match patients with benign breast disease were selected as controls. Serum CK was analyzed by commercially available standardized methods.
RESULTS
Serum CK level was significantly associated with breast cancer (P = 0.005) and subtypes of breast cancer, including breast cancer with diameter>2 cm (P = 0.031) and stage IIIbreast cancer (P = 0.025). The mean serum CK level in patients with>2 cm tumor was significantly lower than that in≤2 cm (P = 0.0475), and the mean serum CK level of stage III breast cancer patients was significantly lower than that of stage I and II breast cancer patients (P = 0.0246). Furthermore, a significant difference (P = 0.004) was observed between serum CK level and ERBB2+breast cancer not other molecular subtypes.
CONCLUSIONS
Serum CK levels in cases was significantly lower compared with controls. Notably, our results indicated for the first time that there was a negative correlation between serum CK levels and breast cancer stage. Serum CK level, which may reflect the status of host immunity, may be an important factor in determining breast cancer development and progression.
背景
先前的研究对肌酸激酶（CK）在恶性肿瘤中的表达和活性提供了模糊的认识。本研究旨在探究血清 CK 水平在乳腺癌患者中的作用。
患者和方法
连续招募了 823 名女性乳腺癌患者作为病例组，另选取 823 名年龄匹配的良性乳腺疾病患者作为对照组。采用市售的标准化方法分析血清 CK。
结果
血清 CK 水平与乳腺癌（P=0.005）及其亚型显著相关，包括直径>2cm 的乳腺癌（P=0.031）和 III 期乳腺癌（P=0.025）。肿瘤直径>2cm 的患者的平均血清 CK 水平明显低于≤2cm 的患者（P=0.0475），III 期乳腺癌患者的平均血清 CK 水平明显低于 I 期和 II 期乳腺癌患者（P=0.0246）。此外，血清 CK 水平与 ERBB2+乳腺癌而非其他分子亚型之间存在显著差异（P=0.004）。
结论
与对照组相比，病例组的血清 CK 水平明显较低。值得注意的是，我们的研究结果首次表明，血清 CK 水平与乳腺癌分期呈负相关。血清 CK 水平可能反映宿主免疫状态，可能是决定乳腺癌发生和进展的重要因素。
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