Poursina Hakim Digestive Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Immunology Department, Medical School, Isfahan University of Medical Sciences, Isfahan, Iran.
J Trace Elem Med Biol. 2023 Jul;78:127153. doi: 10.1016/j.jtemb.2023.127153. Epub 2023 Mar 14.
Turmeric has long been used not only as an indispensable part of Asian cuisine but as a medicinal herb for dressing wounds, bites, burns, treating eye infections and acne. Curcuminoids are the active substances and their synthetic derivatives (i.e. diacetylcurcumin (DAC) and metal-curcumin complexes) possess an incredibly wide range of medicinal properties that encompass chelation capacity for multiple heavy metals, antioxidant activity, anti-inflammatory properties, cytotoxicity against cancerous cells, antiviral and antibacterial effects, antihypertensive and insulin sensitizing role, and regulatory role on apoptosis. The aforementioned properties have put curcumin on spotlight as a potential treatment for ailments such as, hepatic diseases, neurodegenerative diseases, metabolic syndrome, dyslipidemia, cardiovascular disease, auto-immune diseases, malignancies and conditions associated with metal overload. Copper is essential for major biological functions, however, an excess causes chronic ailments including neurodegenerative disorders. The fascinating approach of curcumin could alleviate such effect by forming a complex. Thus, this review aims to present available data on the effect of copper-curcumin interaction in various in vitro, ex-vivo in vivo, and clinical studies.
姜黄不仅长期以来一直作为亚洲菜肴中不可或缺的一部分，而且还作为一种药用植物，用于处理伤口、咬伤、烧伤、眼部感染和痤疮。姜黄素类化合物是活性物质，其合成衍生物（即二乙酰基姜黄素（DAC）和金属姜黄素配合物）具有令人难以置信的广泛的药用特性，包括对多种重金属的螯合能力、抗氧化活性、抗炎特性、对癌细胞的细胞毒性、抗病毒和抗菌作用、降血压和胰岛素增敏作用以及对细胞凋亡的调节作用。上述特性使姜黄成为一种有潜力的治疗方法，可用于治疗肝脏疾病、神经退行性疾病、代谢综合征、血脂异常、心血管疾病、自身免疫性疾病、恶性肿瘤和与金属过载相关的疾病等病症。铜是许多重要生物功能所必需的，但过量会导致慢性疾病，包括神经退行性疾病。姜黄的这种引人注目的方法可以通过形成复合物来减轻这种影响。因此，本综述旨在介绍关于铜-姜黄素相互作用在各种体外、离体和体内以及临床研究中的作用的现有数据。
