Lehmann M, Keul J
Eur J Appl Physiol Occup Physiol. 1986;55(1):14-8. doi: 10.1007/BF00422886.
Urinary excretion of free noradrenaline and adrenaline during 24 h in 265 individuals was determined and related to sex, age, and hypertension as one indicator of the average sympathetic drive. Noradrenaline was found to correlate positively with age in healthy individuals. Noradrenaline and adrenaline were lower in healthy women than in men during the first half of life expectancy. Catecholamine excretion was similar in men and women in the second half of life expectancy. In hypertensive individuals, catecholamine excretion was slightly higher in the first half, and significantly higher in the second half of life expectancy. We assume that the differences in catecholamine excretion can contribute to the sex-and age-related differences in incidence of cardiovascular diseases, such as hypertension and coronary heart disease.
测定了265名个体24小时内游离去甲肾上腺素和肾上腺素的尿排泄量，并将其与性别、年龄以及作为平均交感神经驱动指标之一的高血压相关联。发现去甲肾上腺素在健康个体中与年龄呈正相关。在预期寿命的前半段，健康女性的去甲肾上腺素和肾上腺素水平低于男性。在预期寿命的后半段，男性和女性的儿茶酚胺排泄量相似。在高血压个体中，儿茶酚胺排泄量在预期寿命的前半段略高，而在预期寿命的后半段显著升高。我们认为，儿茶酚胺排泄量的差异可能导致心血管疾病（如高血压和冠心病）发病率的性别和年龄差异。
