Lehmann M, Spöri U, Keul J
Klin Wochenschr. 1985 Mar 15;63(6):264-71. doi: 10.1007/BF01731473.
The 24-h urinary excretion of free catecholamines was evaluated in: 62 healthy and 20 hypertensive (primary hypertension, stage 1 and 2) male subjects, less than or equal to 39 years of age, and in 64 healthy and 44 hypertensive (primary hypertension, stage II and III) male subjects greater than or equal to 40 years of age. Noradrenaline excretion correlates positively with the age, based on the date of all 190 subjects (r = 0.29, P less than 0.001) and for the 126 healthy subjects (r = 0.37, P less than 0.001), however not for the 64 hypertensive patients. Adrenaline and dopamine excretion does not show any significant correlation with the age of the investigated subjects, neither for all 190 subjects nor for the different groups. The noradrenaline-adrenaline ratio also correlates positively with the age (r = 0.28, P less than 0.001, n = 190). The younger hypertensives (less than or equal to 39 years of age) show a slightly but not significantly higher noradrenaline excretion; this, however, is significantly higher in the group of older hypertensive subjects (P less than 0.05; greater than or equal to 40 years of age). No significant differences are recognizable for adrenaline and dopamine excretion between normotensive and hypertensive subjects.
对以下人群的24小时游离儿茶酚胺尿排泄情况进行了评估：62名年龄小于或等于39岁的健康男性受试者以及20名高血压（原发性高血压，1期和2期）男性受试者；还有64名年龄大于或等于40岁的健康男性受试者以及44名高血压（原发性高血压，2期和3期）男性受试者。基于所有190名受试者的数据（r = 0.29，P < 0.001）以及126名健康受试者的数据（r = 0.37，P < 0.001），去甲肾上腺素排泄与年龄呈正相关，但64名高血压患者的数据并非如此。肾上腺素和多巴胺排泄与所研究受试者的年龄均无显著相关性，无论是对于所有190名受试者还是不同组别的受试者。去甲肾上腺素与肾上腺素的比值也与年龄呈正相关（r = 0.28，P < 0.001，n = 190）。较年轻的高血压患者（小于或等于39岁）去甲肾上腺素排泄略有升高，但无显著差异；然而，在年龄较大的高血压患者组中（P < 0.05；大于或等于40岁），去甲肾上腺素排泄显著更高。血压正常者与高血压患者在肾上腺素和多巴胺排泄方面无显著差异。
